A new caffeic acid tetramer from the Dracocephalum moldavica L.

被引：29

作者：

Zhang, Jun-Liang ^{[1
]}

Yan, Ren-Jie ^{[1
]}

Yu, Ning ^{[2
]}

Zhang, Xue ^{[1
]}

Chen, Dai-Jie ^{[1
]}

Wu, Tong ^{[1
]}

Xin, Jian-Guo ^{[2
]}

机构：

[1] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai, Peoples R China

[2] Xinjiang Inst Mat Med, Xinjiang Key Lab Uighur Med, Urumqi, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 03期

关键词：

Dracocephalu mmoldavica L; caffeic acid multimer; primary cardiomyocytes; apoptosis; CHEMICAL-CONSTITUENTS; PHENOLIC-COMPOUNDS;

D O I：

10.1080/14786419.2017.1359168

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new caffeic acid tetramer compound, named (+) methyl rabdosiin (4), together with seven known caffeic acid multimers (1-3, 5-8) and one caffeic acid monomer (9), were isolated from the aerial parts of Dracocephalum moldavica L. The structures of these compounds were assigned on the basis of 1D and 2D NMR spectroscopic and mass spectrometry analyses. The protective effects of compounds 2-4 against hydrogen peroxide (H2O2)-induced apoptosis were evaluated in primary cardiomyocytes of SD neonatal rats in vitro by the MTT method. Three compounds exhibited potent protective activities at 12.5g/mL.

引用

页码：370 / 373

页数：4

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