Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010-2019)

被引：12

作者：

Carvalhaes, Cecilia G. ^{[1
]}

Sader, Helio S. ^{[1
]}

Streit, Jennifer M. ^{[1
]}

Castanheira, Mariana ^{[1
]}

Mendes, Rodrigo E. ^{[1
]}

机构：

[1] JMI Labs, North Liberty, IA 52317 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2022年 / 66卷 / 02期

关键词：

lipoglycopeptides; E; faecium; VRE; VanA; VanB; vancomycin resistance; daptomycin resistance; CARE-ASSOCIATED INFECTIONS; SINGLE-DOSE ORITAVANCIN; ACUTE BACTERIAL SKIN; METHICILLIN-RESISTANT; VANCOMYCIN; HOSPITALS;

D O I：

10.1128/AAC.01667-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oritavancin displayed potent and stable activity (MIC90 range of 0.06 to 05 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (MRSA) and resistant subsets of Enterococcus spp. Daptomycin and linezolid were also active against methicillin-resistant S. aureus and vancomycin-resistant Enterococcus (VRE). Only oritavancin and linezolid remained active against Enterococcus faecium isolates displaying an elevated daptomycin MIC (i.e., 2 to 4 mg/L). Proportions of methicillin-resistant S. aureus and vancomycin-resistant Enterococcus within the respective S. aureus and enterococcal populations decreased over this period.

引用

页数：6

共 5 条

[1] Oritavancin in vitro activity against Gram-positive organisms from European medical centers: a 10-year longitudinal overview from the SENTRY Antimicrobial Surveillance Program (2010-2019)
Pfaller, M. A.
Mendes, R. E.
Sader, H. S.
Castanheira, M.
Carvalhaes, C. G.
JOURNAL OF CHEMOTHERAPY, 2023, 35 (08) : 689 - 699
[2] Ceftobiprole activity against Gram-positive and Gram-negative pathogens causing bone and joint infections in the United States from 2016 to 2020
Duncan, Leonard R.
Hamed, Kamal A.
Smart, Jennifer I.
Pfaller, Michael A.
Flamm, Robert K.
Mendes, Rodrigo E.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2022, 103 (03)
[3] Activity of Tedizolid and Comparator Agents Against Gram-positive Isolates Causing Skin and Skin Structure Infections in Pediatric Patients in United States Hospitals (2015-2019)
Carvalhaes, Cecilia Godoy
Sader, Helio Silva
Rhomberg, Paul Richard
Castanheira, Mariana
DeVries, Sean
Mendes, Rodrigo Elisandro
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2022, 41 (09) : 731 - 735
[4] Oritavancin in vitro activity against gram-positive organisms from European and United States medical centers: results from the SENTRY Antimicrobial Surveillance Program for 2010-2014
Pfaller, M. A.
Sader, H. S.
Flamm, R. K.
Castanheira, M.
Mendes, Rodrigo E.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2018, 91 (02) : 199 - 204
[5] Surveillance of tedizolid activity and resistance: In vitro susceptibility of Gram-positive pathogens collected over 5 years from the United States and Europe
Bensaci, Mekki
Sahm, Daniel
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2017, 87 (02) : 133 - 138

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