Evaluation of lung cancer biomarkers profile for the decision of targeted therapy in EBUS-TBNA cytological samples

被引：4

作者：

Kaya, Aslihan Gurun ^{[1
]}

Ciledag, Aydin ^{[1
]}

Erol, Serhat ^{[1
]}

Oz, Mirac ^{[1
]}

Mulazimoglu, Deniz Dogan ^{[1
]}

Isik, Ozlem ^{[1
]}

Ozakinci, Hilal ^{[2
]}

Ciftci, Fatma ^{[1
]}

Sen, Elif ^{[1
]}

Ceyhan, Koray ^{[2
]}

Kaya, Akin ^{[1
]}

Karnak, Demet ^{[1
]}

Celik, Gokhan ^{[1
]}

Ismail, Savas ^{[1
]}

机构：

[1] Ankara Univ, Dept Chest Dis, Fac Med, TR-06100 Ankara, Turkey

[2] Ankara Univ, Dept Pathol, Fac Med, Ankara, Turkey

来源：

SCOTTISH MEDICAL JOURNAL | 2022年 / 67卷 / 01期

关键词：

Non-small cell lung carcinoma; lung cancer biomarker; molecular analysis; endobronchial ultrasound; targeted therapy; GROWTH-FACTOR RECEPTOR; TRANSBRONCHIAL NEEDLE ASPIRATION; MOLECULAR TESTING GUIDELINE; ENDOBRONCHIAL ULTRASOUND; INTERNATIONAL-ASSOCIATION; MUTATION ANALYSIS; DIAGNOSIS; COLLEGE; EGFR; SPECIMENS;

D O I：

10.1177/00369330221078995

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Guidelines recommend performing biomarker tests for epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), BRAF and ROS proto-oncogene-1(ROS1) genes and protein expression of programmed death ligand-1(PD-L1) in patients with non-small lung cell carcinoma (NSCLC). Studies reported that endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) can provide sufficient material for cancer biomarker analyses, but there are still concerns about the subject. Aim The purpose of the study was to assess the adequacy of EBUS-TBNA for testing lung cancer biomarkers. Methods We retrospectively reviewed patients with NSCLC whose EBUS-TBNA was analysed for EGFR, ALK, ROS-1, BRAF and PD-L1 expression between December 2011 and December 2020. Results A total of 394 patients were enrolled in the study. EGFR mutation and ALK fusion were the most common studied biomarkers. EBUS-TBNA adequacy rate for biomarker tests was found 99.0% for EGFR, 99.1 for ALK, 97.2% for ROS1, 100% for BRAF and 99.3% for PD-L1 testing. Multivariate analysis revealed the histological type, history of treatment for NSCL, size, or 18-fluorodeoxyglucose uptake of sampled lesion did not show any association with TBNA adequacy for biomarker testing. Conclusion EBUS-TBNA can provide adequate material for biomarker testing for EGFR, ALK, ROS-1, BRAF and PD-L1 expression.

引用

页码：18 / 27

页数：10

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