Viral Molecular Characterization of the First Congenital Rubella Syndrome Case in Vietnam

被引：0

作者：

Dinh Nguyen Tran ^{[2
,3
]}

Minh Phuc Vu ^{[3
]}

Manh Tuan Ha ^{[4
]}

Tran Phuong Linh Giang ^{[4
]}

Komase, Katsuhiro ^{[5
]}

Mizuguchi, Masashi ^{[2
]}

Ushijima, Hiroshi ^{[1
]}

机构：

[1] Aino Univ, Aino Hlth Sci Ctr, Tokyo 1500002, Japan

[2] Univ Tokyo, Grad Sch Med, Sch Int Hlth, Dept Dev Med Sci, Tokyo, Japan

[3] Univ Med & Pharm Ho Chi Minh City, Dept Pediat, Ho Chi Minh City, Vietnam

[4] Childrens Hosp 2, Ho Chi Minh City, Vietnam

[5] Natl Inst Infect Dis, Dept Virol 3, Tokyo, Japan

来源：

CLINICAL LABORATORY | 2011年 / 57卷 / 5-6期

关键词：

Congenital rubella syndrome (CRS); molecular diagnosis; Vietnam; DEVELOPING-COUNTRIES; SYNDROME CRS; VACCINATION; PREVENTION; BURDEN;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Rubella virus (RV) infection during the first trimester of pregnancy often leads to severe birth defects known as congenital rubella syndrome (CRS). Methods: A premature newborn male was clinically diagnosed as CRS with cataracts, congenital heart defects, microcephaly, hepatosplenomegaly, and thrombocytopenia. The infection was confirmed serologically and molecularly. Results: The RV was characterized and clustered with the 2B genotype. Conclusions: The integrated description of clinical features, serological and molecular data provide a baseline for diagnosis and control of rubella and CRS in Vietnam. This is the first report of molecular investigation of wildtype RV strain in Vietnam, thus contributing to the documentation of RV's worldwide distribution. (Clin. Lab. 2011;57:397-401)

引用

页码：397 / 401

页数：5

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