Structure of biologically active organotin(IV) dithiocarbamates

被引：0
|
作者：
Farina, Y. [1 ]
Sanuddin, M. [1 ]
Yamin, B. M. [1 ]
机构：
[1] Univ Kebangsaan Malaysia, Sch Chem Sci & Food Technol, Fac Sci & Technol, Bangi 43600, Malaysia
来源：
NEUTRON AND X-RAY SCATTERING IN MATERIALS SCIENCE AND BIOLOGY | 2008年 / 989卷
关键词：
organotin dithiocarbamates; biologically active; structure;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The diorganotin(IV) complexes of dithiocarbamates derived from from N-ethyl-n-propylamine (EtPrdtc), 2-dimethylaminoethylamine (Me(2)Etdtc), 3-dimethlyamino-1-propylamine (Me(2)Prdtc), p-tolylmethanamine (TylMetdtc) and N-methyl-1-phenyhnethanamine (MePhMetdtc) have been synthesized and characterized. Single crystal X-ray diffraction studies on Ph3Sn(EtPrdtc), Me2Sn(MePhMetdtc)(2) and BU2Sn(McPhMetdtc)(2) showed that the complexes adopted a monoclinic system with space group P(2)/n, P2(1)/n and C2/c, respectively. The Ph3Sn(EtPrdtc) complex adopted a trigonal pyramidal structure while the Me2Sn(MePhMetdtC)(2) and Bu2Sn(MePhMet)(2) complexes displayed structures which may be described as distorted octahedrons. Cytotoxicity test using BL60 cells (human promyelocytic leukemic) showed that only Me2Sn(Me(2)Etdtc), Me2Sn(MePhMetdtc)(2) and BU2Sn(MePhMetdtc)(2) complexes were active. The rest of the complexes did not show cytotoxicity behaviour towards BL60 cells.
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页码：221 / 223
页数：3
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