PRETEXT II-III multifocal hepatoblastoma: significance of resection of satellite lesions irrespective of their disappearance after chemotherapy

被引:9
作者
Qureshi, Sajid S. [1 ]
Bhagat, Monica [1 ]
Kembhavi, Seema [2 ]
Vora, Tushar [3 ]
Ramadwar, Mukta [4 ]
Talole, Sanjay [5 ]
机构
[1] Tata Mem Hosp, Dept Surg Oncol, Div Pediat Surg Oncol, Bombay 400012, Maharashtra, India
[2] Tata Mem Hosp, Dept Radiol, Bombay, Maharashtra, India
[3] Tata Mem Hosp, Div Pediat Oncol, Dept Med Oncol, Bombay 400012, Maharashtra, India
[4] Tata Mem Hosp, Dept Pathol, Bombay 400012, Maharashtra, India
[5] Tata Mem Hosp, Dept Biostat, Bombay 400012, Maharashtra, India
关键词
Hepatoblastoma; Multifocal; Surgery; Chemotherapy; Satellite lesions; High risk; TUMOR STRATEGY GROUP; LIVER-TRANSPLANTATION; INTERNATIONAL-SOCIETY; UNRESECTABLE HEPATOBLASTOMA; CENTER EXPERIENCE; MODERN-ERA; CHILDREN; SIOPEL;
D O I
10.1007/s00383-015-3713-0
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To determine the outcomes of resection of satellite lesions in PRE-treatment Tumor EXTension (PRETEXT) II and III multifocal hepatoblastoma irrespective of their disappearance after chemotherapy. To compare the overall outcomes of multifocal and unifocal hepatoblastoma. Fourteen patients with PRETEXT II (n = 7) and III (n = 7) multifocal hepatoblastoma treated between April 2006 and July 2014 were analyzed and their outcomes were compared with PRETEXT II and III unifocal hepatoblastoma treated in the similar period. Satellite lesion or the affected segments with disappeared satellite lesions were resected in 11 patients. Amongst them, all relapses were distant except one in the liver. In contrast, two of three patients developed liver relapse when the affected segments were not resected. None of the patients receiving intensive chemotherapy based on SIOPEL-3 guidelines developed a relapse. The 3-year event-free and overall survival were 38.6 and 42.9 % in multifocal hepatoblastoma and 86.4 and 92.4 % in unifocal hepatoblastoma (p = 0.001). Multifocality (p = 0.002) and AFP > 10,000 after induction chemotherapy significantly affected event-free survival (p = 0.01). Multifocal hepatoblastoma is associated with poor outcomes as compared to unifocal hepatoblastoma. These preliminary observations of relapse and the role of chemotherapy intensification deserve further study in a multicenter controlled trial setting.
引用
收藏
页码:573 / 579
页数:7
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