Are "resting" microglia more "M2"?

被引：65
作者：
Cherry, Jonathan D. [1 ]
Olschowka, A. [2 ]
O'Banion, M. Kerry [2 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Pathol & Lab Med, Rochester, NY 14642 USA
[2] Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷
关键词：
microglia; M2; alternative activation; neuroinflammation; resting; activation; ALTERNATIVE ACTIVATION; EXPRESSION; BRAIN; NEUROINFLAMMATION; INFLAMMATION; MACROPHAGES; CELLS; IMMUNITY; MEMORY;
D O I：
10.3389/fimmu.2014.00594
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页数：4
相关论文
共 38 条
[1]   Local self-renewal can sustain CNS microglia maintenance and function throughout adult life [J].
Ajami, Bahareh ;
Bennett, Jami L. ;
Krieger, Charles ;
Tetzlaff, Wolfram ;
Rossi, Fabio M. V. .
NATURE NEUROSCIENCE, 2007, 10 (12) :1538-1543
[2]   Inflammation in neurodegenerative diseases [J].
Amor, Sandra ;
Puentes, Fabiola ;
Baker, David ;
van der Valk, Paul .
IMMUNOLOGY, 2010, 129 (02) :154-169
[3]   CYTOTOXICITY OF MICROGLIA [J].
BANATI, RB ;
GEHRMANN, J ;
SCHUBERT, P ;
KREUTZBERG, GW .
GLIA, 1993, 7 (01) :111-118
[4]   Identification of a unique TGF-β dependent molecular and functional signature in microglia [J].
Butovsky, Oleg ;
Jedrychowski, Mark P. ;
Moore, Craig S. ;
Cialic, Ron ;
Lanser, Amanda J. ;
Gabriely, Galina ;
Koeglsperger, Thomas ;
Dake, Ben ;
Wu, Pauline M. ;
Doykan, Camille E. ;
Fanek, Zain ;
Liu, LiPing ;
Chen, Zhuoxun ;
Rothstein, Jeffrey D. ;
Ransohoffl, Richard M. ;
Gygi, Steven P. ;
Antel, Jack P. ;
Weiner, Howard L. .
NATURE NEUROSCIENCE, 2014, 17 (01) :131-143
[5]   Phagosome maturation in polarized macrophages [J].
Canton, Johnathan .
JOURNAL OF LEUKOCYTE BIOLOGY, 2014, 96 (05) :729-738
[6]   Neuroinflammation and M2 microglia: the good, the bad, and the inflamed [J].
Cherry, Jonathan D. ;
Olschowka, John A. ;
O'Banion, M. Kerry .
JOURNAL OF NEUROINFLAMMATION, 2014, 11
[7]   MULTIPLE DEFECTS OF IMMUNE CELL-FUNCTION IN MICE WITH DISRUPTED INTERFERON-GAMMA GENES [J].
DALTON, DK ;
PITTSMEEK, S ;
KESHAV, S ;
FIGARI, IS ;
BRADLEY, A ;
STEWART, TA .
SCIENCE, 1993, 259 (5102) :1739-1742
[8]   Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS [J].
De Haas, Alexander H. ;
Boddeke, Hendrikus W. G. M. ;
Biber, Knut .
GLIA, 2008, 56 (08) :888-894
[9]   Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice [J].
Derecki, Noel C. ;
Quinnies, Kayla M. ;
Kipnis, Jonathan .
BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (03) :379-385
[10]   Regulation of learning and memory by meningeal immunity: a key role for IL-4 [J].
Derecki, Noel C. ;
Cardani, Amber N. ;
Yang, Chun Hui ;
Quinnies, Kayla M. ;
Crihfield, Anastasia ;
Lynch, Kevin R. ;
Kipnis, Jonathan .
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (05) :1067-1080
1234