Self-adhesive hydrogels for tissue engineering

被引:74
作者
Yi, Yating [1 ]
Xie, Chaoming [2 ]
Liu, Jin [3 ,4 ]
Zheng, Yonghao [5 ]
Wang, Jun [1 ]
Lu, Xiong [2 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis,Dept Orthodont, Chengdu 610041, Sichuan, Peoples R China
[2] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Lab Aging Res, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu 610041, Sichuan, Peoples R China
[5] Univ Elect Sci & Technol China, Sch Optoelect Sci & Technol, Chengdu 610054, Peoples R China
关键词
ARTICULAR-CARTILAGE REPAIR; CHONDROITIN SULFATE; INSPIRED ADHESIVE; SUPRAMOLECULAR HYDROGELS; BIOACTIVE HYDROGELS; CARDIAC-FUNCTION; REGENERATION; POLYMER; TOUGH; CHITOSAN;
D O I
10.1039/d1tb01503f
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Hydrogels consisting of a three-dimensional hydrophilic network of biocompatible polymers have been widely used in tissue engineering. Owing to their tunable mechanical properties, hydrogels have been applied in both hard and soft tissues. However, most hydrogels lack self-adhesive properties that enable integration with surrounding tissues, which may result in suture or low repair efficacy. Self-adhesive hydrogels (SAHs), an emerging class of hydrogels based on a combination of three-dimensional hydrophilic networks and self-adhesive properties, continue to garner increased attention in recent years. SAHs exhibit reliable and suitable adherence to tissues, and easily integrate into tissues to promote repair efficiency. SAHs are designed either by mimicking the adhesion mechanism of natural organisms, such as mussels and sandcastle worms, or by using supramolecular strategies. This review summarizes the design and processing strategies of SAHs, clarifies underlying adhesive mechanisms, and discusses their applications in tissue engineering, as well as future challenges.
引用
收藏
页码:8739 / 8767
页数:29
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