Transition-Metal-Free N-Functionalization of Benzimidazoles and Related Azaheterocycles with α-Acyloxy Sulfides

被引：1
|
作者：
Fang, Yingchao [1 ,2 ]
Wang, Manman [1 ,2 ]
Hao, Wei [1 ,2 ]
Meng, Yinggao [1 ,2 ]
Yu, Wenquan [1 ,2 ]
Chang, Junbiao [1 ,2 ]
机构：
[1] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 17期
基金：
中国国家自然科学基金;
关键词：
N-functionalization; transition-metal-free; benzimidazole; azaheterocycle; alpha-acyloxy sulfide; MARKOVNIKOV ADDITION; VINYL ESTERS; MILD-STEEL; DERIVATIVES; INHIBITORS; PRODRUG; HETEROCYCLES; ADSORPTION; ALKALOIDS; CORROSION;
D O I：
10.1002/adsc.202200502
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Direct N-functionalization of benzimidazoles and related azaheterocycles has been achieved using readily accessible alpha-acyloxy sulfides under transition metal-free conditions. In the presence of the base, potassium carbonate, a variety of N-functionalized azaheterocyclic compounds bearing an N-alkyl ester moiety were synthesized from corresponding heterocyclic precursors. The present reaction does not use transition metals, is operationally simple, and has broad substrate scope.
引用
收藏
页码：2922 / 2925
页数：4
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