Application of accelerator mass spectrometry (AMS) in early drug development. Part 1. Background and procedures

被引：0
|
作者：
Lipner, Grzegorz [1 ]
Grynkiewicz, Grzegorz [1 ]
机构：
[1] Inst Farmaceuty, Zakladzie Chem, PL-01793 Warsaw, Poland
来源：
PRZEMYSL CHEMICZNY | 2012年 / 91卷 / 03期
关键词：
IN-VIVO; PHARMACOKINETICS; EXPERIENCE; FUTURE; VOLUNTEERS; NUCLEAR; MEIQX; MICE; DNA;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A review, with 40 refs., and fundamentals of combined applications of linear accelerator and high resolution mass spectrometer for detection of org. compds. containing suitable C-14 labels in femtomol concns. for studying pharmacokinetic parameters and metabolic fate of drugs from single sub-pharmacolog. dose.
引用
收藏
页码：314 / 318
页数：5
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