DNA nanotechnology

被引：1372

作者：

Seeman, Nadrian C. ^{[1
]}

Sleiman, Hanadi F. ^{[2
]}

机构：

[1] NYU, Dept Chem, 100 Washington Sq East, New York, NY 10003 USA

[2] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A0B8, Canada

来源：

NATURE REVIEWS MATERIALS | 2018年 / 3卷 / 01期

基金：

加拿大自然科学与工程研究理事会; 美国国家科学基金会; 加拿大健康研究院;

关键词：

SINGLE-STRANDED-DNA; DOUBLE-CROSSOVER MOLECULES; SEQUENCE-DEFINED POLYMERS; EXPANDED GENETIC ALPHABET; SOLID-PHASE SYNTHESIS; ORIGAMI NANOSTRUCTURES; PLASMONIC NANOSTRUCTURES; GOLD NANOPARTICLES; SEMISYNTHETIC ORGANISM; TEMPLATED SYNTHESIS;

D O I：

10.1038/natrevmats.2017.68

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

DNA is the molecule that stores and transmits genetic information in biological systems. The field of DNA nanotechnology takes this molecule out of its biological context and uses its information to assemble structural motifs and then to connect them together. This field has had a remarkable impact on nanoscience and nanotechnology, and has been revolutionary in our ability to control molecular self-assembly. In this Review, we summarize the approaches used to assemble DNA nanostructures and examine their emerging applications in areas such as biophysics, diagnostics, nanoparticle and protein assembly, biomolecule structure determination, drug delivery and synthetic biology. The introduction of orthogonal interactions into DNA nanostructures is discussed, and finally, a perspective on the future directions of this field is presented.

引用

页数：23

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