Concern over transmission of viral infections has been reported to result in higher discard rates of high infectious risk kidneys (HIR) although data on actual viral transmission rates are lacking. At our center, we performed 89 HIR and 533 non-HIR kidney transplants (KTs) between 2004 and 2011. Follow-up screening labs in recipients of HIR kidneys tested for human immunodeficiency virus, hepatitis C virus, and hepatitis B virus did not reveal any cases of viral transmission over median follow-up of 4.3 years. Patient and graft outcomes were similar at 5 years between HIR and non-HIR KTs. An updated analysis of the Organ Procurement and Transplant Network (OPTN) registry of deceased-donor kidney transplants between 2008 and 2012 included 57 526 transplants was performed. Retrospective calculation of KDRI (kidney donor risk index) differed (P<.001) between all groups with median KDRI of 0.99 for HIR kidneys, 1.07 for non-HIR standard criteria donor kidneys, and 1.81 for non-HIR expanded criteria donor (ECD) kidneys. This was reflected in the significantly improved 5-year graft survival for HIR KTs when compared with non-HIR ECD KTs (84% vs 78%; P<.001). Our data can guide counseling of KT candidates about the safety and benefits of HIR kidneys.
机构:
Univ Michigan Hlth Syst, Dept Anesthesiol, Ann Arbor, MI USAUniv Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
Duan, K. I.
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Englesbe, M. J.
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Volk, M. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
Univ Michigan Hlth Syst, Ctr Behav & Decis Sci Med, Ann Arbor, MI USAUniv Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
机构:
Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Div Organ Transplantat, Chicago, IL 60611 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Ison, M. G.
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Llata, E.
论文数: 0引用数: 0
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机构:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Llata, E.
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Conover, C. S.
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机构:
Illinois Dept Publ Hlth, Branch Lab, Div HIV AIDS Prevent, Div Infect Dis, Springfield, IL 62761 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Conover, C. S.
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Friedewald, J. J.
论文数: 0引用数: 0
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机构:
Northwestern Univ, Feinberg Sch Med, Div Organ Transplantat, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Div Nephrol Hypertens, Chicago, IL 60611 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Friedewald, J. J.
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Gerberg, S. I.
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机构:
Cook Cty Dept Publ Hlth, Chicago, IL USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Gerberg, S. I.
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Grigoryan, A.
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Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Grigoryan, A.
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Heneine, W.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Heneine, W.
;
Millis, J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Sect Transplantat, Chicago, IL 60637 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Millis, J. M.
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Simon, D. M.
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机构:
Rush Univ, Med Ctr, Infect Dis Sect, Chicago, IL 60612 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Simon, D. M.
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Teo, C. -G.
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机构:
Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Teo, C. -G.
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Kuehnert, M. J.
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h-index: 0
机构:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
机构:
Univ Michigan Hlth Syst, Dept Anesthesiol, Ann Arbor, MI USAUniv Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
Duan, K. I.
;
论文数: 引用数:
h-index:
机构:
Englesbe, M. J.
;
Volk, M. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
Univ Michigan Hlth Syst, Ctr Behav & Decis Sci Med, Ann Arbor, MI USAUniv Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
机构:
Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Div Organ Transplantat, Chicago, IL 60611 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Ison, M. G.
;
Llata, E.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Llata, E.
;
Conover, C. S.
论文数: 0引用数: 0
h-index: 0
机构:
Illinois Dept Publ Hlth, Branch Lab, Div HIV AIDS Prevent, Div Infect Dis, Springfield, IL 62761 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Conover, C. S.
;
Friedewald, J. J.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Div Organ Transplantat, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Div Nephrol Hypertens, Chicago, IL 60611 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Friedewald, J. J.
;
Gerberg, S. I.
论文数: 0引用数: 0
h-index: 0
机构:
Cook Cty Dept Publ Hlth, Chicago, IL USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Gerberg, S. I.
;
Grigoryan, A.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Grigoryan, A.
;
Heneine, W.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Heneine, W.
;
Millis, J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Sect Transplantat, Chicago, IL 60637 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Millis, J. M.
;
Simon, D. M.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Infect Dis Sect, Chicago, IL 60612 USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Simon, D. M.
;
Teo, C. -G.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Teo, C. -G.
;
Kuehnert, M. J.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USACtr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA