Synthesis of New S-alkylated-3-mercapto-1,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents

被引：0

作者：

Murty, M. S. R. ^{[1
]}

Ram, Kesur R. ^{[1
]}

Rao, Rayudu Venkateswara ^{[1
]}

Yadav, J. S. ^{[1
]}

Rao, Janapala Venkateswara ^{[2
]}

Pamanji, R. ^{[2
]}

Velatooru, L. R. ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Biol, Toxicol Unit, Hyderabad 500607, Andhra Pradesh, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2012年 / 9卷 / 03期

关键词：

1,2,4-Triazoles; Acid hydrazides; Piperazines; Anticancer; ANTIBACTERIAL; TRIAZOLES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-[3-[4-(Substituted)-1-cyclicamine]propyl]thio-5-substituted[1,2,4]triazoles (8a-j) were synthesized with good yields starting from corresponding carboxylic acids. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Three compounds had shown good anticancer activity. The triazole derivatives, 8i and 8j were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinants of their biological activity.

引用

页码：276 / 281

页数：6

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