Direct and indirect recognition: the role of MHC antigens in graft rejection

被引：262

作者：

Gould, DS

Auchincloss, H

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Massachusetts Gen Hosp, Transplantat Unit, Dept Surg, Boston, MA 02144 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0167-5699(98)01394-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In graft rejection, T-cell stimulation by donor APCs and self-APCs (presenting peptides of donor origin) has been called 'direct' and 'indirect' recognition, respectively. Here, Dina Gould and Hugh Auchincloss consider the traditional arguments favoring direct recognition and highlight recent findings suggesting the importance of indirect responses, thereby questioning some of our basic concepts of transplantation immunology.

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页码：77 / 82

页数：6

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