Molecular and absorption properties of 12 soy isoflavones and their structure-activity relationship with selected biological activities

被引:25
作者
Chun, HS [1 ]
Chang, HJ [1 ]
Choi, EH [1 ]
Kim, HJ [1 ]
Ku, KH [1 ]
机构
[1] Korea Food Res Inst, Sungnam 463746, Kyonggi Do, South Korea
关键词
cytochrome P4501; proliferation of osteoblastic cells; quinone reductase; soy isoflavones; structure-activity relationship;
D O I
10.1007/s10529-005-8457-9
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Three biological activities of 12 soy isoflavones were investigated in terms of the structure-activity relationship. Seven molecular descriptors and one absorption predictor were significantly related to the inhibition of cytochrome P4501 activity in HepG2 cells by soy isoflavones, yielding water solubility [correlation coefficient (gamma)=-0.779] and hydrophobicity (gamma=0.718) as more relevant molecular properties. By contrast, the inducing activities of 12 soy isoflavones both on quinone reductase in HepG2 cells and proliferation of the osteoblastic MG-63 cells demonstrated significant correlation to the hydroxyl and methoxyl substituents on the isoflavone skeleton (p < 0.01).
引用
收藏
页码:1105 / 1111
页数:7
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