Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

被引：381
|
作者：
Sun, Chun-Yi [1 ]
Qin, Chao [1 ]
Wang, Chun-Gang [1 ]
Su, Zhong-Min [1 ]
Wang, Shuang [1 ]
Wang, Xin-Long [1 ]
Yang, Guang-Sheng [1 ]
Shao, Kui-Zhan [1 ]
Lan, Ya-Qian [1 ]
Wang, En-Bo [1 ]
机构：
[1] NE Normal Univ, Dept Chem, Inst Funct Mat Chem, Key Lab Polyoxometalate Sci,Minist Educ, Changchun 130024, Jilin, Peoples R China
来源：
ADVANCED MATERIALS | 2011年 / 23卷 / 47期
关键词：
porous materials; metal-organic frameworks; biomedical applications; drug delivery; ADSORPTION; SURFACE; FUNCTIONALIZATION; VALIDATION; RELEASE; STORAGE;
D O I：
10.1002/adma.201102538
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on a nontoxic zinc and achiral hexadentate ligand. It shows high drug loading and slow release of the proportion of the loaded drug with a complete delivery time of about one week when used as a material for adsorption and delivery of anticancer 5-fluorouracil.
引用
收藏
页码：5629 / +
页数：5
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