Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

被引：381

作者：

Sun, Chun-Yi ^{[1
]}

Qin, Chao ^{[1
]}

Wang, Chun-Gang ^{[1
]}

Su, Zhong-Min ^{[1
]}

Wang, Shuang ^{[1
]}

Wang, Xin-Long ^{[1
]}

Yang, Guang-Sheng ^{[1
]}

Shao, Kui-Zhan ^{[1
]}

Lan, Ya-Qian ^{[1
]}

Wang, En-Bo ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Inst Funct Mat Chem, Key Lab Polyoxometalate Sci,Minist Educ, Changchun 130024, Jilin, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 47期

关键词：

porous materials; metal-organic frameworks; biomedical applications; drug delivery; ADSORPTION; SURFACE; FUNCTIONALIZATION; VALIDATION; RELEASE; STORAGE;

D O I：

10.1002/adma.201102538

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on a nontoxic zinc and achiral hexadentate ligand. It shows high drug loading and slow release of the proportion of the loaded drug with a complete delivery time of about one week when used as a material for adsorption and delivery of anticancer 5-fluorouracil.

引用

页码：5629 / +

页数：5

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