Photoreceptors in diabetic retinopathy

被引：102

作者：

Kern, Timothy S. ^{[1
,2
,3
]}

Berkowitz, Bruce A. ^{[4
,5
]}

机构：

[1] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[2] Ctr Diabet Res, Cleveland, OH USA

[3] Vet Adm Med Ctr Res Serv 151, Cleveland, OH USA

[4] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA

[5] Wayne State Univ, Sch Med, Dept Ophthalmol, Detroit, MI USA

来源：

JOURNAL OF DIABETES INVESTIGATION | 2015年 / 6卷 / 04期

关键词：

Diabetes; Diabetic retinopathy; Photoreceptors; RETINAL INSULIN-RECEPTOR; MANGANESE-ENHANCED MRI; OXYGEN DISTRIBUTION; DARK-ADAPTATION; OXIDATIVE STRESS; VISUAL-ACUITY; EARLY-STAGE; RHODOPSIN REGENERATION; RETINITIS-PIGMENTOSA; ION REGULATION;

D O I：

10.1111/jdi.12312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although photoreceptors account for most of the mass and metabolic activity of the retina, their role in the pathogenesis of diabetic retinopathy has been largely overlooked. Recent studies suggest that photoreceptors might play a critical role in the diabetes-induced degeneration of retinal capillaries, and thus can no longer be ignored. The present review summarizes diabetes-induced alterations in photoreceptor structure and function, and provides a rationale for further study of a role of photoreceptors in the pathogenesis of the retinopathy.

引用

页码：371 / 380

页数：10

共 123 条

[71] Effect of long-term administration of α-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
Kowluru, RA
Odenbach, S
[J]. DIABETES, 2004, 53 (12) : 3233 - 3238
[72] Abnormalities of retinal metabolism in diabetes and experimental galactosemia VII. Effect of long-term administration of antioxidants on the development of retinopathy
Kowluru, RA
Tang, J
Kern, TS
[J]. DIABETES, 2001, 50 (08) : 1938 - 1942
[73] TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy
Kowluru, Renu A.
Kowluru, Anjaneyulu
Veluthakal, Rajakrishnan
Mohammad, Ghulam
Syed, Ismail
Santos, Julia M.
Mishra, Manish
[J]. DIABETOLOGIA, 2014, 57 (05) : 1047 - 1056
[74] Calcium regulation in photoreceptors
Krizaj, D
Copenhagen, DR
[J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2002, 7 : D2023 - D2044
[75] Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats
Kumar, Binit
Gupta, Suresh Kumar
Srinivasan, B. P.
Nag, Tapas Chandra
Srivastava, Sushma
Saxena, Rohit
Jha, Kumar Abhiram
[J]. MICROVASCULAR RESEARCH, 2013, 87 : 65 - 74
[76] Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats
Kusari, Jyotirmoy
Zhou, Sheila
Padillo, Edwin
Clarke, Kenneth G.
Gil, Daniel W.
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (11) : 5152 - 5159
[77] Effect of lipoic acid on expression of angiogenic factors in diabetic rat retina
Lee, Sul Gee
Lee, Chang Gun
Yun, Il Han
Hur, Dae Young
Yang, Jae Wook
Kim, Hyun Woong
[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2012, 40 (01) : E47 - E57
[78] Early retinal damage in experimental diabetes: Electroretinographical and morphological observations
Li, Q
Zemel, E
Miller, B
Perlman, I
[J]. EXPERIMENTAL EYE RESEARCH, 2002, 74 (05) : 615 - 625
[79] Manganese ion enhances T-1-weighted MRI during brain activation: An approach to direct imaging of brain function
Lin, YJ
Koretsky, AP
[J]. MAGNETIC RESONANCE IN MEDICINE, 1997, 38 (03) : 378 - 388
[80] EFFECTS OF LIGHT AND DARKNESS ON OXYGEN DISTRIBUTION AND CONSUMPTION IN THE CAT RETINA
LINSENMEIER, RA
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1986, 88 (04) : 521 - 542

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