Photoreceptors in diabetic retinopathy

被引：102

作者：

Kern, Timothy S. ^{[1
,2
,3
]}

Berkowitz, Bruce A. ^{[4
,5
]}

机构：

[1] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[2] Ctr Diabet Res, Cleveland, OH USA

[3] Vet Adm Med Ctr Res Serv 151, Cleveland, OH USA

[4] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA

[5] Wayne State Univ, Sch Med, Dept Ophthalmol, Detroit, MI USA

来源：

JOURNAL OF DIABETES INVESTIGATION | 2015年 / 6卷 / 04期

关键词：

Diabetes; Diabetic retinopathy; Photoreceptors; RETINAL INSULIN-RECEPTOR; MANGANESE-ENHANCED MRI; OXYGEN DISTRIBUTION; DARK-ADAPTATION; OXIDATIVE STRESS; VISUAL-ACUITY; EARLY-STAGE; RHODOPSIN REGENERATION; RETINITIS-PIGMENTOSA; ION REGULATION;

D O I：

10.1111/jdi.12312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although photoreceptors account for most of the mass and metabolic activity of the retina, their role in the pathogenesis of diabetic retinopathy has been largely overlooked. Recent studies suggest that photoreceptors might play a critical role in the diabetes-induced degeneration of retinal capillaries, and thus can no longer be ignored. The present review summarizes diabetes-induced alterations in photoreceptor structure and function, and provides a rationale for further study of a role of photoreceptors in the pathogenesis of the retinopathy.

引用

页码：371 / 380

页数：10

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