EGFR and KRAS mutations and altered c-Met gene copy numbers in primary non-small cell lung cancer and associated stage N2 lymph node-metastasis

被引：30

作者：

Han, Cheng-Bo ^{[1
]}

Ma, Jie-Tao ^{[1
]}

Li, Fan ^{[2
]}

Zhao, Jian-Zhu ^{[1
]}

Jing, Wei ^{[1
]}

Zhou, Yang ^{[1
]}

Zou, Hua-Wei ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Oncol 1, Shenyang 110022, Peoples R China

[2] China Med Univ, Coll Basic Sci, Shenyang 110001, Peoples R China

来源：

CANCER LETTERS | 2012年 / 314卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Non-small cell lung cancer; Epidermal growth factor receptor; KRAS; MET; Mutation; Gene copy number; TYROSINE KINASE INHIBITORS; CLINICAL-IMPLICATIONS; ACQUIRED-RESISTANCE; PRIMARY TUMORS; GEFITINIB; HETEROGENEITY; AMPLIFICATION; EXPRESSION; BIOMARKERS;

D O I：

10.1016/j.canlet.2011.09.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study aimed to detect mutations in EGFR and KRAS and alterations of c-Met gene copy number (GCN) changes in primary and lymph node-metastatic NSCLCs. The data showed the concordant rate of EGFR genotype in primary and stage N2 lymph node-metastatic tumors was 95.45%. c-Met GCN in stage N2 lymph nodes was significantly higher than that of the primary tumors (P = 0.038). The results suggest both primary and lymph-node metastases have relatively consistent EGFR mutations and EGFR mutations are not relevant to changes in c-Met GCN. c-Met GCN was increased significantly in EGFR TKI-naive patients with lymph node-metastatic tumors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：63 / 72

页数：10

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