Neutrophil, quo vadis?

被引：31

作者：

Jablonska, Jadwiga ^{[1
]}

Granot, Zvi ^{[2
]}

机构：

[1] Univ Hosp Essen, Dept Otorhinolaryngol, Translat Oncol, Essen, Germany

[2] Hebrew Univ Hadassah Med Sch, Inst Med Res Israel Canada, Dept Dev Biol & Canc Res, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2017年 / 102卷 / 03期

基金：

以色列科学基金会;

关键词：

normal density neutrophils; low density neutrophils; neutrophil subsets; TUMOR-ASSOCIATED NEUTROPHILS; REGULATORY T-CELLS; MICE; POLARIZATION; PLASTICITY; DISEASE;

D O I：

10.1189/jlb.3MR0117-015R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neutrophils were traditionally considered to be a homogeneous population of terminally differentiated cells with very defined roles in inflammation and fighting infections. However, recent advances in neutrophil research challenge this limited view and demonstrate that neutrophils are highly versatile, play different roles in various pathologic scenarios, and are heterogeneous. With this, it is becoming clear that one termneutrophilis too general, and more precise nomenclature is urgently required. In this mini review, we discuss the knowns and unknowns in neutrophil terminology and highlight the critical questions that should be addressed for the establishment of clear neutrophil nomenclature.

引用

页码：685 / 688

页数：4

共 38 条

[11] Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: "N1" versus "N2" TAN [J].

Fridlender, Zvi G. ;

Sun, Jing ;

Kim, Samuel ;

Kapoor, Veena ;

Cheng, Guanjun ;

Ling, Leona ;

Worthen, G. Scott ;

Albelda, Steven M. .

CANCER CELL, 2009, 16 (03) :183-194

[12] Distinct Functions of Neutrophil in Cancer and Its Regulation [J].

Granot, Zvi ;

Jablonska, Jadwiga .

MEDIATORS OF INFLAMMATION, 2015, 2015

[13] Plasticity beyond Cancer Cells and the "Immunosuppressive Switch" [J].

Granot, Zvi ;

Fridlender, Zvi G. .

CANCER RESEARCH, 2015, 75 (21) :4441-4445

[14] Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung [J].

Granot, Zvi ;

Henke, Erik ;

Comen, Elizabeth A. ;

King, Tari A. ;

Norton, Larry ;

Benezra, Robert .

CANCER CELL, 2011, 20 (03) :300-314

[15] Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model (vol 120, pg 1151, 2010) [J].

Jablonska, Jadwiga ;

Leschner, Sara ;

Westphal, Kathrin ;

Lienenklaus, Stefan ;

Weiss, Siegfried .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (11) :4163-4163

[16] Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes [J].

Ku, Amy W. ;

Muhitch, Jason B. ;

Powers, Colin A. ;

Diehl, Michael ;

Kim, Minhyung ;

Fisher, Daniel T. ;

Sharda, Anand P. ;

Clements, Virginia K. ;

O'Loughlin, Kieran ;

Minderman, Hans ;

Messmer, Michelle N. ;

Ma, Jing ;

Skitzki, Joseph J. ;

Steeber, Douglas A. ;

Walcheck, Bruce ;

Ostrand-Rosenberg, Suzanne ;

Abrams, Scott I. ;

Evans, Sharon S. .

ELIFE, 2016, 5

[17] Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis [J].

Lin, Andrew M. ;

Rubin, Cory J. ;

Khandpur, Ritika ;

Wang, Jennifer Y. ;

Riblett, MaryBeth ;

Yalavarthi, Srilakshmi ;

Villanueva, Eneida C. ;

Shah, Parth ;

Kaplan, Mariana J. ;

Bruce, Allen T. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (01) :490-500

[18] Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease [J].

Lood, Christian ;

Blanco, Luz P. ;

Purmalek, Monica M. ;

Carmona-Rivera, Carmelo ;

De Ravin, Suk S. ;

Smith, Carolyne K. ;

Malech, Harry L. ;

Ledbetter, Jeffrey A. ;

Elkon, Keith B. ;

Kaplan, Mariana J. .

NATURE MEDICINE, 2016, 22 (02) :146-153

[19] Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression [J].

Lopez-Lago, M. A. ;

Posner, S. ;

Thodima, V. J. ;

Molina, A. M. ;

Motzer, R. J. ;

Chaganti, R. S. K. .

ONCOGENE, 2013, 32 (14) :1752-1760

[20] Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans [J].

Massena, Sara ;

Christoffersson, Gustaf ;

Vagesjo, Evelina ;

Seignez, Cedric ;

Gustafsson, Karin ;

Binet, Francois ;

Hidalgo, Carmen Herrera ;

Giraud, Antoine ;

Lomei, Jalal ;

Westrom, Simone ;

Shibuya, Masabumi ;

Claesson-Welsh, Lena ;

Gerwins, Par ;

Welsh, Michael ;

Kreuger, Johan ;

Phillipson, Mia .

BLOOD, 2015, 126 (17) :2016-2026

← 1 2 3 4 →