Toll-like receptors in inflammation of the central nervous system

被引：137
作者：
Kong, Yan [1 ]
Le, Yingying [2 ]
机构：
[1] Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Peoples R China
[2] Chinese Acad Sci, SIBS, Inst Nutr Sci, Lab Nutr & Inflammat Related Dis, Shanghai 200031, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Toll-like receptors; Central nervous system; Inflammation; Infection; Injury; Autoimmune diseases; FOCAL CEREBRAL-ISCHEMIA; HERPES-SIMPLEX-VIRUS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; INNATE IMMUNITY; STAPHYLOCOCCUS-AUREUS; MULTIPLE-SCLEROSIS; BRAIN-INJURY; LETHAL ENCEPHALITIS; MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1016/j.intimp.2011.04.025
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize exogenous pathogen-associated molecular patterns and endogenous damage-associated molecular patterns. TLRs play pivotal roles in innate and adaptive immune responses. In this review we summarize the ligands and signal transduction pathways of TLRs and highlight recent progress of the involvement of TLRs in neuroinflammation related disorders, including cerebral ischemia/stroke, brain trauma and hemorrhage, pathogen infection and autoimmune diseases, and explore the potential of TLR signaling as therapeutic targets against these disorders. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1407 / 1414
页数：8
相关论文
共 116 条
  • [1] Toll-like receptor signalling
    Akira, S
    Takeda, K
    [J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) : 499 - 511
  • [2] Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
    Andersson, Asa
    Covacu, Ruxandra
    Sunnemark, Dan
    Danilov, Alexandre I.
    Dal Bianco, Assunta
    Khademi, Mohsen
    Wallstrom, Erik
    Lobell, Anna
    Brundin, Lou
    Lassmann, Hans
    Harris, Robert A.
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (05) : 1248 - 1255
  • [3] Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia
    Aravalli, Rajagopal N.
    Hu, Shuxian
    Lokensgard, James R.
    [J]. JOURNAL OF NEUROINFLAMMATION, 2007, 4
  • [4] Toll-like receptors in defense and damage of the central nervous system
    Aravalli, Rajagopal N.
    Peterson, Phillip K.
    Lokensgard, James R.
    [J]. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2007, 2 (04) : 297 - 312
  • [5] Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling
    Aravalli, Rajagopal N.
    Hu, Shuxian
    Woods, Jon P.
    Lokensgard, James R.
    [J]. JOURNAL OF NEUROINFLAMMATION, 2008, 5 (1)
  • [6] Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus
    Aravalli, RN
    Hu, SX
    Rowen, TN
    Palmquist, JM
    Lokensgard, JR
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 175 (07) : 4189 - 4193
  • [7] Toll-like receptor 2 signaling in response to brain injury: An innate bridge to neuroinflammation
    Babcock, Alicia A.
    Wirenfeldt, Martin
    Holm, Thomas
    Nielsen, Helle H.
    Dissing-Olesen, Lasse
    Toft-Hansen, Henrik
    Millward, Jason M.
    Landmann, Regine
    Rivest, Serge
    Finsen, Bente
    Owens, Trevor
    [J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (49) : 12826 - 12837
  • [8] TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Bafica, A
    Scanga, CA
    Feng, CG
    Leifer, C
    Cheever, A
    Sher, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (12) : 1715 - 1724
  • [9] High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?
    Bjorkhem, I.
    Lovgren-Sandblom, A.
    Piehl, F.
    Khademi, M.
    Pettersson, H.
    Leoni, V.
    Olsson, T.
    Diczfalusy, U.
    [J]. JOURNAL OF LIPID RESEARCH, 2011, 52 (01) : 170 - 174
  • [10] Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis
    Boivin, Nicolas
    Sergerie, Yan
    Rivest, Serge
    Boivin, Guy
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (05) : 664 - 672
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