Synthesis of 11C-labelled acamprosate for PET studies

被引：6
作者：
Courtyn, J
Goethals, P
Van der Eycken, J
Dams, R
机构：
[1] State Univ Ghent, Inst Nucl Sci, Analyt Chem Lab, B-9000 Ghent, Belgium
[2] State Univ Ghent, Dept Organ Chem, Lab Organ & Bioorgan Synth, B-9000 Ghent, Belgium
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2001年 / 44卷 / 09期
关键词：
C-11]acamprosate; C-11]N-acetyl homotaurinate; PET; biodistribution; alcohol;
D O I：
10.1002/jlcr.490
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A method for labelling acamprosate (calcium N-acetyl homotaurinate), an anti-craving compound For ethanol, with C-11. has been developed for in vivo studies with positron emission tomography (PET). The synthesis was based on the acylation of homotaurinate using [C-11]acetyl chloride as the labelling agent. Reversed-phase HPLC in highly aqueous mobile phase conditions was used for product purification. The radiochemical yield achieved was about 1.14 GBq (31 mCi) with a specific radioactivity of 8.14 GBq/mu mol (220 mCi/mu mol). For the identification of C-11-radioactivity and determination of specific radioactivities, HPLC and H-1-NMR were used, Copyright (C), 2001 John Wiley & Sons. Ltd.
引用
收藏
页码：643 / 651
页数：9
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