The Blood-Brain Barrier Challenge for the Treatment of Brain Cancer, Secondary Brain Metastases, and Neurological Diseases

被引：0
作者：
Weidle, Ulrich H. [1 ]
Niewoethner, Jens [1 ]
Tiefenthaler, Georg [1 ]
机构：
[1] Roche Diagnost GmbH, Roche Innovat Ctr Penzberg, Roche Pharma Res & Early Dev, D-82372 Penzberg, Germany
来源：
CANCER GENOMICS & PROTEOMICS | 2015年 / 12卷 / 04期
关键词：
Antibody-effector protein fusion; antibody-antibody fusion; tropism of metastasis; transferrin receptor; insulin receptor; animal metastasis models; receptor-mediated endocytosis; molecular Trojan horses; review; ANTITRANSFERRIN RECEPTOR ANTIBODY; MOUSE TRANSFERRIN RECEPTOR; NERVOUS-SYSTEM METASTASES; BREAST-CANCER; MONOCLONAL-ANTIBODY; IN-VIVO; FUSION PROTEIN; LUNG-CANCER; ADJUVANT TRASTUZUMAB; ENDOTHELIAL-CELLS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Formation of metastases from various tumor entities in the brain is a major problem for the treatment of advanced cancer. We describe target molecules and tools for the delivery of small molecules or proteins across the blood-brain barrier (BBB), and the treatment of brain tumors and metastases with antibody-related moieties. In addition, drugs preventing formation of metastases or interfering with the growth of established metastases are described, as well as pre-clinical metastasis models and corresponding clinical data. Furthermore, we discuss the delivery of effector proteins and antibody-based moieties fused with an antibody-based scaffold across the BBB in several model systems which might be applicable for the treatment of brain metastases.
引用
收藏
页码：167 / 177
页数：11
相关论文
共 122 条
[1]   The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells [J].
Abulrob, A ;
Sprong, H ;
Henegouwen, PVBE ;
Stanimirovic, D .
JOURNAL OF NEUROCHEMISTRY, 2005, 95 (04) :1201-1214
[2]   Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases [J].
Adamo, Barbara ;
Deal, Allison M. ;
Burrows, Emily ;
Geradts, Joseph ;
Hamilton, Erika ;
Blackwell, Kimberly L. ;
Livasy, Chad ;
Fritchie, Karen ;
Prat, Aleix ;
Harrell, J. Chuck ;
Ewend, Matthew G. ;
Carey, Lisa A. ;
Miller, C. Ryan ;
Anders, Carey K. .
BREAST CANCER RESEARCH, 2011, 13 (06)
[3]   Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts [J].
Baschnagel, Andrew ;
Russo, Andrea ;
Burgan, William E. ;
Carter, Donna ;
Beam, Katie ;
Palmieri, Diane ;
Steeg, Patricia S. ;
Tofilon, Philip ;
Camphausen, Kevin .
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (06) :1589-1595
[4]   Breaching the Blood-Brain Barrier for Drug Delivery [J].
Bell, Robert D. ;
Ehlers, Michael D. .
NEURON, 2014, 81 (01) :1-3
[5]   Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma [J].
Bendell, JC ;
Domchek, SM ;
Burstein, HJ ;
Harris, L ;
Younger, J ;
Kuter, I ;
Bunnell, C ;
Rue, M ;
Gelman, R ;
Winer, E .
CANCER, 2003, 97 (12) :2972-2977
[6]   Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1 [J].
Bertrand, Y. ;
Currie, J-C ;
Poirier, J. ;
Demeule, M. ;
Abulrob, A. ;
Fatehi, D. ;
Stanimirovic, D. ;
Sartelet, H. ;
Castaigne, J-P ;
Beliveau, R. .
BRITISH JOURNAL OF CANCER, 2011, 105 (11) :1697-1707
[7]   Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier [J].
Boado, Ruben J. ;
Zhang, Yufeng ;
Zhang, Yun ;
Pardridge, William M. .
BIOTECHNOLOGY AND BIOENGINEERING, 2007, 97 (06) :1376-1386
[8]   Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and Aβ fibril disaggregation [J].
Boado, Ruben J. ;
Zhang, Yufeng ;
Zhang, Yun ;
Xia, Chun-Fang ;
Pardridge, William M. .
BIOCONJUGATE CHEMISTRY, 2007, 18 (02) :447-455
[9]   Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor [J].
Boado, Ruben J. ;
Zhou, Qing-Hui ;
Lu, Jeff Zhiqiang ;
Hui, Eric Ka-Wai ;
Pardridge, William M. .
MOLECULAR PHARMACEUTICS, 2010, 7 (01) :237-244
[10]   Engineering and Expression of a Chimeric Transferrin Receptor Monoclonal Antibody for Blood-Brain Barrier Delivery in the Mouse [J].
Boado, Ruben J. ;
Zhang, Yun ;
Wang, Yuntao ;
Pardridge, William M. .
BIOTECHNOLOGY AND BIOENGINEERING, 2009, 102 (04) :1251-1258
12345678910