O-GIcNAcylation in Cancer Biology: Linking Metabolism and Signaling

被引：216

作者：

Ferrer, Christina M. ^{[1
]}

Sodi, Valerie L. ^{[1
]}

Reginato, Mauricio J. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2016年 / 428卷 / 16期

关键词：

glycosylation; signaling; cancer; O-GIcNAcylation; OGT; N-ACETYLGLUCOSAMINE TRANSFERASE; FATTY-ACID SYNTHASE; GLCNAC TRANSFERASE; CELL-GROWTH; HEXOSAMINE BIOSYNTHESIS; TET PROTEINS; GLCNACYLATION; PATHWAY; OGT; GLYCOSYLATION;

D O I：

10.1016/j.jmb.2016.05.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of beta-D-N-acetylglucosamine sugars to nuclear and cytoplasmic proteins. Increased total O-GIcNAcylation is emerging as a general characteristic of cancer cells, and recent studies suggest that O-GIcNAcylation is a central communicator of nutritional status to control key signaling and metabolic pathways that regulate multiple cancer cell phenotypes. This review summarizes our current understanding of changes of O-GIcNAc cycling enzymes in cancer, the role of O-GIcNAcylation in tumorigenesis, and the current challenges in targeting this pathway therapeutically. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3282 / 3294

页数：13

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