Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

被引：10

作者：

Strub, Daniel Jan ^{[1
,2
]}

Talma, Michal ^{[3
]}

Strub, Maria ^{[2
]}

Rut, Wioletta ^{[1
]}

Zmudzinski, Mikolaj ^{[1
]}

Brud, Wladyslaw ^{[4
]}

Neyts, Johan ^{[5
]}

Vangeel, Laura ^{[5
]}

Zhang, Linlin ^{[6
]}

Sun, Xinyuanyuan ^{[6
]}

Lv, Zongyang ^{[7
,8
,9
]}

Nayak, Digant ^{[7
,8
,9
]}

Olsen, Shaun K. ^{[7
,8
,9
]}

Hilgenfeld, Rolf ^{[6
,10
]}

Jochmans, Dirk ^{[5
]}

Drag, Marcin ^{[1
]}

机构：

[1] Wroclaw Univ Sci & Technol, Dept Chem Biol & Bioimaging, Wyb Wyspianskiego 27, PL-50370 Wroclaw, Poland

[2] Liquid Technol Sp Zoo, Gdanska 13, PL-50344 Wroclaw, Poland

[3] Wroclaw Univ Sci & Technol, Dept Bioorgan Chem, Wyb Wyspianskiego 27, PL-50370 Wroclaw, Poland

[4] TC Grp, Sci Comm Int Federat Essential Oils & Aroma Trade, Level 1,Devonshire House,One Mayfair Pl, London W1J 8AJ, England

[5] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Virol & Chemotherapy, Rega Inst, Leuven, Belgium

[6] Univ Lubeck, Inst Mol Med, Ratzeburger Allee 160, D-23562 Lubeck, Germany

[7] Med Univ South Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA

[8] Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA

[9] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA

[10] Univ Lubeck, German Ctr Infect Res DZIF, Hamburg Lubeck Borstel Riems Site, D-23562 Lubeck, Germany

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

ACUTE RESPIRATORY SYNDROME; PROTEASE INHIBITORS; IN-VITRO; CORONAVIRUS; IDENTIFICATION; DISCOVERY; VOLATILE;

D O I：

10.1038/s41598-022-18676-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Essential oils and aromatic extracts (oleoresins, absolutes, concretes, resinoids) are often used as food flavorings and constituents of fragrance compositions. The flavor and fragrance industry observed significant growth in the sales of some natural materials during the COVID-19 outbreak. Some companies worldwide are making false claims regarding the effectiveness of their essential oils or blends (or indirectly point toward this conclusion) against coronaviruses, even though the available data on the activity of plant materials against highly pathogenic human coronaviruses are very scarce. Our exploratory study aimed to develop pioneering knowledge and provide the first experimental results on the inhibitory properties of hundreds of flavor and fragrance materials against SARS-CoV-2 main and papain-like proteases and the antiviral potential of the most active protease inhibitors. As essential oils are volatile products, they could provide an interesting therapeutic strategy for subsidiary inhalation in the long term.

引用

页数：14

共 50 条

[31] Development of indigenous IgG ELISA for the detection of anti-SARS-CoV-2 IgG [J].

Sapkal, Gajanan ;

Shete-Aich, Anita ;

Jain, Rajlaxmi ;

Yadav, Pragya D. ;

Sarkale, Prasad ;

Lakra, Rajen ;

Baradkar, Srikant ;

Deshpande, Gururaj Rao ;

Mali, Deepak ;

Tilekar, Bipin N. ;

Majumdar, Triparna ;

Kaushal, Himanshu ;

Gurav, Yogesh ;

Gupta, Nivedita ;

Mohandas, Sreelekshmy ;

Deshpande, Ketki ;

Kaduskar, Ojas ;

Salve, Malvika ;

Patil, Savita ;

Gaikwad, Shivshankar ;

Sugunan, A. P. ;

Ashok, M. ;

Giri, Sidhartha ;

Shastri, Jayanthi ;

Abraham, Priya ;

Gangakhedkar, Raman R. .

INDIAN JOURNAL OF MEDICAL RESEARCH, 2020, 151 (05) :444-449

[32] Anti-SARS-CoV-2 Titers Predict the Severity of COVID-19 [J].

Kritikos, Antonios ;

Gabellon, Sophie ;

Pagani, Jean-Luc ;

Monti, Matteo ;

Bochud, Pierre-Yves ;

Manuel, Oriol ;

Coste, Alix ;

Greub, Gilbert ;

Perreau, Matthieu ;

Pantaleo, Giuseppe ;

Croxatto, Antony ;

Lamoth, Frederic .

VIRUSES-BASEL, 2022, 14 (05)

[33] Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties [J].

Fawazy, Nehmedo G. ;

Panda, Siva S. ;

Mostafa, Ahmed ;

Kariuki, Benson M. ;

Bekheit, Mohamed S. ;

Moatasim, Yassmin ;

Kutkat, Omnia ;

Fayad, Walid ;

El-Manawaty, May A. ;

Soliman, Ahmed A. F. ;

El-Shiekh, Riham A. ;

Srour, Aladdin M. ;

Barghash, Reham F. ;

Girgis, Adel S. .

SCIENTIFIC REPORTS, 2022, 12 (01)

[34] Exploration of phenolic acid derivatives as inhibitors of SARS-CoV-2 main protease and receptor binding domain: potential candidates for anti-SARS-CoV-2 therapy [J].

Shafiq, Nusrat ;

Mehroze, Aiman ;

Sarwar, Warda ;

Arshad, Uzma ;

Parveen, Shagufta ;

Rashid, Maryam ;

Farooq, Ariba ;

Rafiq, Naila ;

Wondmie, Gezahign Fentahun ;

Bin Jardan, Yousef A. ;

Brogi, Simone ;

Bourhia, Mohammed .

FRONTIERS IN CHEMISTRY, 2023, 11

[35] Repurposing of Four Drugs as Anti-SARS-CoV-2 Agents and Their Interactions with Protein Targets [J].

Vesga, Luis C. ;

Ruiz-Hernandez, Camilo A. ;

Alvarez-Jacome, Jeimmy J. ;

Duque, Jonny E. ;

Rincon-Orozco, Bladimiro ;

Mendez-Sanchez, Stelia C. .

SCIENTIA PHARMACEUTICA, 2022, 90 (02)

[36] Natural coumarins as potential anti-SARS-CoV-2 agents supported by docking analysis [J].

Abdelmohsen, Usama Ramadan ;

Albohy, Amgad ;

Abdulrazik, Basma S. ;

Bayoumi, Soad A. L. ;

Malak, Lourin G. ;

Khallaf, Iman S. A. ;

Bringmann, Gerhard ;

Farag, Salwa F. .

RSC ADVANCES, 2021, 11 (28) :16970-16979

[37] Recruitment of chalcone's potential in drug discovery of anti-SARS-CoV-2 agents [J].

Valipour, Mehdi .

PHYTOTHERAPY RESEARCH, 2022, 36 (12) :4477-4490

[38] Structure- and Interaction-Based Design of Anti-SARS-CoV-2 Aptamers [J].

Mironov, Vladimir ;

Shchugoreva, Irina A. ;

Artyushenko, Polina, V ;

Morozov, Dmitry ;

Borbone, Nicola ;

Oliviero, Giorgia ;

Zamay, Tatiana N. ;

Moryachkov, Roman, V ;

Kolovskaya, Olga S. ;

Lukyanenko, Kirill A. ;

Song, Yanling ;

Merkuleva, Iuliia A. ;

Zabluda, Vladimir N. ;

Peters, Georgy ;

Koroleva, Lyudmila S. ;

Veprintsev, Dmitry V. ;

Glazyrin, Yury E. ;

Volosnikova, Ekaterina A. ;

Belenkaya, Svetlana, V ;

Esina, Tatiana, I ;

Isaeva, Anastasiya A. ;

Nesmeyanova, Valentina S. ;

Shanshin, Daniil, V ;

Berlina, Anna N. ;

Komova, Nadezhda S. ;

Svetlichnyi, Valery A. ;

Silnikov, Vladimir N. ;

Shcherbakov, Dmitriy N. ;

Zamay, Galina S. ;

Zamay, Sergey S. ;

Smolyarova, Tatyana ;

Tikhonova, Elena P. ;

Chen, Kelvin H-C ;

Jeng, U-Ser ;

Condorelli, Gerolama ;

Franciscis, Vittorio ;

Groenhof, Gerrit ;

Yang, Chaoyong ;

Moskovsky, Alexander A. ;

Fedorov, Dmitri G. ;

Tomilin, Felix N. ;

Tan, Weihong ;

Alexeev, Yuri ;

Berezovski, Maxim, V ;

Kichkailo, Anna S. .

CHEMISTRY-A EUROPEAN JOURNAL, 2022, 28 (12)

[39] Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities [J].

Chen, Xuwen ;

Li, Hongtao ;

Wang, Meiting ;

Sun, Donghui ;

Lu, Jiani ;

Zhu, Tong ;

Chen, Hongzhuan ;

Chen, Lili ;

Liu, Shunying .

JOURNAL OF NATURAL PRODUCTS, 2024, 87 (12) :2680-2694

[40] Can Natural Killer Cells Be a Principal Player in Anti-SARS-CoV-2 Immunity? [J].

Ahmed, Faria ;

Jo, Dong-Hyeon ;

Lee, Seung-Hwan .

FRONTIERS IN IMMUNOLOGY, 2020, 11

← 1 2 3 4 5 →