Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system

被引:89
作者
Beppu, Toru [1 ]
Hayashi, Hiromitsu [1 ]
Okabe, Hirohisa [1 ]
Masuda, Toshiro [1 ]
Mima, Kosuke [1 ]
Otao, Ryu [1 ]
Chikamoto, Akira [1 ]
Doi, Koichi [1 ]
Ishiko, Takatoshi [1 ]
Takamori, Hiroshi [1 ]
Yoshida, Morikatsu [2 ]
Shiraishi, Shinya [2 ]
Yamashita, Yasuyuki [2 ]
Baba, Hideo [1 ]
机构
[1] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Kumamoto 8608556, Japan
[2] Kumamoto Univ, Grad Sch Med Sci, Dept Diagnost Radiol, Kumamoto 8608556, Japan
关键词
Portal vein embolization; Tc-99m-Galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system; Functional liver volume; EXTENDED HEPATECTOMY; HEPATOCELLULAR-CARCINOMA; ATTENUATION CORRECTION; MAJOR HEPATECTOMY; RESECTION; CT; PREDICTOR; CANCER; SAFETY;
D O I
10.1007/s00535-011-0406-x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We developed a new combined Tc-99m-galactosyl human serum albumin (GSA) scintigraphy single-photon emission computed tomography (SPECT)/CT system to evaluate the changes in functional liver volume with portal vein embolization (PVE). We performed a prospective analysis of 25 patients treated with right PVE, and evaluated their functional liver volume perioperatively with a Tc-99m-GSA scintigraphy SPECT-CT fusion system. The percentage of the non-tumorous remnant liver volume (%LV) and the percentage of functional remnant liver volume (%FLV) were estimated by using the following calculations: (future remnant volume - tumor volume)/(total liver volume - tumor volume) and functional future remnant liver volume/functional total liver volume, respectively. Before PVE, the correlation was strongly significant between %LV and %FLV of the non-embolized liver, and the data were nearly equal (the regression coefficient was 1.005, P < 0.0001). In contrast, after PVE, there was a significant correlation between %LV and %FLV (P < 0.0001), but the regression coefficient was 1.192. The % LV increased significantly, from 38.1 to 52.0%, and the increment was 13.9% (P < 0.0005). The %FLV was also increased significantly, from 36.6 to 58.0%, and the increment was 21.4% (P < 0.0001). The increment was 7.5% greater for the %FLV compared to that of the %LV (P < 0.001). The Tc-99m-GSA scintigraphy SPECT-CT fusion system can estimate the correct functional liver volume and is useful in comparison with conventional CT volumetry.
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收藏
页码:938 / 943
页数:6
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