Role of Autophagy in Cardiovascular Disease and Aging

被引：12
作者：
Koutouroushis, Christos [1 ]
Sarkar, Oiendrila [1 ]
机构：
[1] Isle Wight NHS Trust, St Marys Hosp, Gen Internal Med, Newport, Shrops, England
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 11期
关键词：
risk factors of cardiovascular diseases; mtor; sirtuins; igf-1; signalling; ampk; cellular aging; therapeutic fasting; caloric-restriction; autophagy; NITRIC-OXIDE BIOAVAILABILITY; ACTIVATED PROTEIN-KINASE; LIFE-SPAN; DEFECTIVE AUTOPHAGY; OXIDATIVE STRESS; HEART; MITOCHONDRIAL; ARTERIAL; RESTRICTION; HOMEOSTASIS;
D O I：
10.7759/cureus.20042
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular disease is the leading cause of death worldwide and is expected to further increase as people continue to live even longer. Although the life span of the general population is increasing, the con of such a prolonged life span is that aging has certain detrimental effects on the molecular, structural, and functional elements of the cardiovascular system. This review will discuss various molecular pathways linked to longevity, most notably autophagy and its associated mechanisms, and how these pathways can be targeted to promote cardiovascular health through the process of aging. It is to be noted that the process of autophagy decreases with aging; hence, this review concludes that the promotion of autophagy, through implementation of caloric restriction, intermittent fasting, and pharmacologic agents, has proven to be an efficacious means of stimulating cardiovascular health. Therefore, autophagy is an important target for prevention and procrastination of cardiovascular pathologies in the geriatric population.
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页数：18
相关论文
共 92 条
[81]   AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction [J].
Turdi, Subat ;
Fan, Xiujuan ;
Li, Ji ;
Zhao, Junxing ;
Huff, Anna F. ;
Du, Min ;
Ren, Jun .
AGING CELL, 2010, 9 (04) :592-606
[82]   Reduced insulin/IGF-1 signalling and human longevity [J].
van Heemst, D ;
Beekman, M ;
Mooijaart, SP ;
Heijmans, BT ;
Brandt, BW ;
Zwaan, BJ ;
Slagboom, PE ;
Westendorp, RGJ .
AGING CELL, 2005, 4 (02) :79-85
[83]   Genetics -: Influence of TOR kinase on lifespan in C-elegans [J].
Vellai, T ;
Takacs-Vellai, K ;
Zhang, Y ;
Kovacs, AL ;
Orosz, L ;
Müller, F .
NATURE, 2003, 426 (6967) :620-620
[84]   Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L [J].
Wang, Qilong ;
Wu, Shengnan ;
Zhu, Huaiping ;
Ding, Ye ;
Dai, Xiaoyan ;
Ouyang, Changhan ;
Han, Young-min ;
Xie, Zhonglin ;
Zou, Ming-Hui .
AUTOPHAGY, 2017, 13 (02) :404-422
[85]   Caloric restriction: powerful protection for the aging heart and vasculature [J].
Weiss, Edward P. ;
Fontana, Luigi .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 301 (04) :H1205-H1219
[86]   Insulin-Like Growth factor 1: At the crossroads of brain development and aging [J].
Wrigley, Sarah ;
Arafa, Donia ;
Tropea, Daniela .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2017, 11
[87]   Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression [J].
Wu, J. Julie ;
Liu, Jie ;
Chen, Edmund B. ;
Wang, Jennifer J. ;
Cao, Liu ;
Narayan, Nisha ;
Fergusson, Marie M. ;
Rovira, Ilsa I. ;
Allen, Michele ;
Springer, Danielle A. ;
Lago, Cory U. ;
Zhang, Shuling ;
DuBois, Wendy ;
Ward, Theresa ;
deCabo, Rafael ;
Gavrilova, Oksana ;
Mock, Beverly ;
Finkel, Toren .
CELL REPORTS, 2013, 4 (05) :913-920
[88]  
Ylä-Anttila P, 2009, AUTOPHAGY, V5, P1180
[89]   Autophagy: molecular machinery for self-eating [J].
Yorimitsu, T ;
Klionsky, DJ .
CELL DEATH AND DIFFERENTIATION, 2005, 12 (Suppl 2) :1542-1552
[90]   Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels [J].
Yuan, Rong ;
Tsaih, Shirng-Wern ;
Petkova, Stefka B. ;
de Evsikova, Caralina Marin ;
Xing, Shuqin ;
Marion, Michael A. ;
Bogue, Molly A. ;
Mills, Kevin D. ;
Peters, Luanne L. ;
Bult, Carol J. ;
Rosen, Clifford J. ;
Sundberg, John P. ;
Harrison, David E. ;
Churchill, Gary A. ;
Paigen, Beverly .
AGING CELL, 2009, 8 (03) :277-287
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