Enzymatic and non-enzymatic activities of SHIP-1 in signal transduction and cancer

被引：38

作者：

Conde, Claude ^{[1
]}

Gloire, Geoffrey ^{[1
]}

Piette, Jacques ^{[1
]}

机构：

[1] Univ Liege, Lab Virol & Immunol, GIGA Res B34, B-4000 Liege, Belgium

来源：

BIOCHEMICAL PHARMACOLOGY | 2011年 / 82卷 / 10期

关键词：

SHIP-1; Grb2; Shc; Dok-1/2; immune response; FC-GAMMA-RIIB; SH2-CONTAINING INOSITOL PHOSPHATASE; DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE; PHOSPHOINOSITIDE 3-KINASE PATHWAY; POLYPHOSPHATE 5-PHOSPHATASE SHIP; COLONY-STIMULATING FACTOR; NEGATIVE REGULATION; LIPID PHOSPHATASE; BONE-MARROW; MAST-CELLS;

D O I：

10.1016/j.bcp.2011.05.031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

PI3K cascade is a central signaling pathway regulating cell proliferation, growth, differentiation, and survival. Tight regulation of the PI3K signaling pathway is necessary to avoid aberrant cell proliferation and cancer development. Together with SHIP-1, the inositol phosphatases PTEN and SHIP-2 are the gatekeepers of this pathway. In this review, we will focus on SHIP-1 functions. Negative regulation of immune cell activation by SHIP-1 is well characterized. Besides its catalytic activity, SHIP-1 also displays non-enzymatic activity playing role in several immune pathways. Indeed, SHIP-1 exhibits several domains that mediate protein-protein interaction. This review emphasizes the negative regulation of immune cell activation by SHIP-1 that is mediated by its protein-protein interaction. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1320 / 1334

页数：15

共 104 条

[11] The lipid phosphatase SHIP2 controls insulin sensitivity (vol 409, pg 92, 2001) [J].

Clément, S ;

Krause, U ;

Desmedt, F ;

Tanti, JF ;

Behrends, J ;

Pesesse, X ;

Sasaki, T ;

Penninger, J ;

Doherty, M ;

Malaisse, W ;

Dumont, JE ;

Le Marchand-Brustel, Y ;

Erneux, C ;

Hue, L ;

Schurmans, S .

NATURE, 2004, 431 (7010) :878-878

[12] The lipid phosphatase SHIP2 controls insulin sensitivity [J].

Clément, S ;

Krause, U ;

Desmedt, F ;

Tanti, JF ;

Behrends, J ;

Pesesse, X ;

Sasaki, T ;

Penninger, J ;

Doherty, M ;

Malaisse, W ;

Dumont, JE ;

Le Marchand-Brustel, Y ;

Erneux, C ;

Hue, L ;

Schurmans, S .

NATURE, 2001, 409 (6816) :92-97

[13] SHIP limits immunoregulatory capacity in the T-cell compartment [J].

Collazo, Michelle M. ;

Wood, Daniela ;

Paraiso, Kim H. T. ;

Lund, Erin ;

Engelman, Robert W. ;

Le, Cam-Tien ;

Stauch, Diana ;

Kotsch, Katja ;

Kerr, William G. .

BLOOD, 2009, 113 (13) :2934-2944

[14] Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice [J].

Costinean, S ;

Zanesi, N ;

Pekarsky, Y ;

Tili, E ;

Volinia, S ;

Heerema, N ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7024-7029

[15] Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice [J].

Costinean, Stefan ;

Sandhu, Sukhinder K. ;

Pedersen, Irene M. ;

Tili, Esmerina ;

Trotta, Rossana ;

Perrotti, Danilo ;

Ciarlariello, David ;

Neviani, Paolo ;

Harb, Jason ;

Kauffman, Lauren Rachel ;

Shidham, Aaditya ;

Croce, Carlo Maria .

BLOOD, 2009, 114 (07) :1374-1382

[16] Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils [J].

Daigle, I ;

Yousefi, S ;

Colonna, M ;

Green, DR ;

Simon, HU .

NATURE MEDICINE, 2002, 8 (01) :61-67

[17] The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase [J].

Damen, JE ;

Liu, L ;

Rosten, P ;

Humphries, RK ;

Jefferson, AB ;

Majerus, PW ;

Krystal, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (04) :1689-1693

[18] Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation [J].

Damen, JE ;

Liu, L ;

Ware, MD ;

Ermolaeva, M ;

Majerus, PW ;

Krystal, G .

BLOOD, 1998, 92 (04) :1199-1205

[19] SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation [J].

Damen, JE ;

Ware, MD ;

Kalesnikoff, J ;

Hughes, MR ;

Krystal, G .

BLOOD, 2001, 97 (05) :1343-1351

[20] T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2 [J].

Dong, Shen ;

Corre, Beatrice ;

Foulon, Eliane ;

Dufour, Evelyne ;

Veillette, Andre ;

Acuto, Oreste ;

Michel, Frederique .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (11) :2509-2518

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