Enzymatic and non-enzymatic activities of SHIP-1 in signal transduction and cancer

被引：38
作者：
Conde, Claude [1 ]
Gloire, Geoffrey [1 ]
Piette, Jacques [1 ]
机构：
[1] Univ Liege, Lab Virol & Immunol, GIGA Res B34, B-4000 Liege, Belgium
来源：
BIOCHEMICAL PHARMACOLOGY | 2011年 / 82卷 / 10期
关键词：
SHIP-1; Grb2; Shc; Dok-1/2; immune response; FC-GAMMA-RIIB; SH2-CONTAINING INOSITOL PHOSPHATASE; DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE; PHOSPHOINOSITIDE 3-KINASE PATHWAY; POLYPHOSPHATE 5-PHOSPHATASE SHIP; COLONY-STIMULATING FACTOR; NEGATIVE REGULATION; LIPID PHOSPHATASE; BONE-MARROW; MAST-CELLS;
D O I：
10.1016/j.bcp.2011.05.031
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
PI3K cascade is a central signaling pathway regulating cell proliferation, growth, differentiation, and survival. Tight regulation of the PI3K signaling pathway is necessary to avoid aberrant cell proliferation and cancer development. Together with SHIP-1, the inositol phosphatases PTEN and SHIP-2 are the gatekeepers of this pathway. In this review, we will focus on SHIP-1 functions. Negative regulation of immune cell activation by SHIP-1 is well characterized. Besides its catalytic activity, SHIP-1 also displays non-enzymatic activity playing role in several immune pathways. Indeed, SHIP-1 exhibits several domains that mediate protein-protein interaction. This review emphasizes the negative regulation of immune cell activation by SHIP-1 that is mediated by its protein-protein interaction. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：1320 / 1334
页数：15
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