Cytoplasmic dynein

被引：116
作者：
Allan, Victoria J. [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷
基金：
英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
Bicaudal D (BicD); cytoplasmic dynein; dynactin; lissencephaly 1 (LIS1); microtubule; Nde; 1; INTERMEDIATE CHAIN 1; TUG-OF-WAR; MICROTUBULE PLUS ENDS; AXONAL-TRANSPORT; LIGHT-CHAIN; REGULATES TRANSPORT; NEURONAL MIGRATION; MEDIATED TRANSPORT; DYNACTIN COMPLEX; MOLECULAR MOTORS;
D O I：
10.1042/BST0391169
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of nnicrotubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's mechanochemistry, how it is regulated and how it binds to such a plethora of cargoes. The importance of a number of accessory factors in these processes is discussed.
引用
收藏
页码：1169 / 1178
页数：10
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