Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells

被引：12
|
作者：
Ohguchi, Kenji [1 ]
Koike, Minako [2 ]
Suwa, Yoshihide [2 ]
Koshimizu, Seiichi [3 ]
Mizutani, Yuki [4 ]
Nozawa, Yoshinori [1 ]
Akao, Yukihiro [1 ]
机构：
[1] Gifu Int Inst Biotechnol, Gifu 5040838, Japan
[2] Suntory Ltd, Res Ctr, Osaka 6168503, Japan
[3] Suntory Ltd, Whisky Blending & Planning Dept, Osaka 6168503, Japan
[4] KOSE Corp, Div Res & Dev, Itabashi Ku, Tokyo 1740051, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 04期
关键词：
whisky congeners; melanin; melanogenesis; tyrosinase;
D O I：
10.1271/bbb.70734
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.
引用
收藏
页码：1107 / 1110
页数：4
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