Interaction of dendritic cells with biomaterials

被引：60
作者：
Abensee, Julia E. B. [1 ,2 ]
机构：
[1] Georgia Inst Technol, Wallance H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[2] Emory Univ, Atlanta, GA 30332 USA
来源：
SEMINARS IN IMMUNOLOGY | 2008年 / 20卷 / 02期
关键词：
biomaterials; combination products; dendritic cells; adjuvant; danger signals;
D O I：
10.1016/j.smim.2007.10.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interconnections between innate and adaptive immunity, with a focus on dendritic cells (DCs), in the context of combination products, are discussed. Biomaterials are shown to act as an adjuvant in the enhancement of the adaptive immune response to co-delivered antigen. Biomaterials are considered as agonists for DC maturation and several hypotheses as to the mechanism by which DCs recognize and respond to biomaterials are presented. There is the conceptualization of biomaterials with the idea of 'danger signals'. The goal is to design biomaterials to control DC phenotype and in this way control immune responses to combination products. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：101 / 108
页数：8
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