Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea

被引：28

作者：

Singh, Sharon A. ^{[2
]}

Koumbourlis, Anastassios C. ^{[2
]}

Aygun, Banu ^{[1
,2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol, Memphis, TN 38105 USA

[2] Schneider Childrens Hosp, Albert Einstein Coll Med, New Hyde Pk, NY 11042 USA

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 50卷 / 06期

关键词：

hydroxyurea; hypoxemia; sickle cell anemia;

D O I：

10.1002/pbc.21480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly after they were treated with hydroxyurea despite having additional risk factors for hypoxemia. A prospective trial is warranted to assess whether there is a therapeutic effect from the use of hydroxyurea in pediatric SCA patients with chronic hypoxemia.

引用

页码：1258 / 1260

页数：3

共 12 条

[1] EFFECT OF HYDROXYUREA ON THE FREQUENCY OF PAINFUL CRISES IN SICKLE-CELL-ANEMIA [J].

CHARACHE, S ;

TERRIN, ML ;

MOORE, RD ;

DOVER, GJ ;

BARTON, FB ;

ECKERT, SV ;

MCMAHON, RP ;

BONDS, DR ;

ORRINGER, E ;

JONES, S ;

STRAYHORN, D ;

ROSSE, W ;

PHILLIPS, G ;

PEACE, D ;

JOHNSONTELFAIR, A ;

MILNER, P ;

KUTLAR, A ;

TRACY, A ;

BALLAS, SK ;

ALLEN, GE ;

MOSHANG, J ;

SCOTT, B ;

STEINBERG, M ;

ANDERSON, A ;

SABAHI, V ;

PEGELOW, C ;

TEMPLE, D ;

CASE, E ;

HARRELL, R ;

CHILDERIE, S ;

EMBURY, S ;

SCHMIDT, B ;

DAVIES, D ;

KOSHY, M ;

TALISCHYZAHED, N ;

DORN, L ;

PENDARVIS, G ;

MCGEE, M ;

TELFER, M ;

DAVIS, A ;

CASTRO, O ;

FINKE, H ;

PERLIN, E ;

SITEMAN, J ;

GASCON, P ;

DIPAOLO, P ;

GARGIULO, S ;

ECKMAN, J ;

BAILEY, JH ;

PLATT, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1317-1322

[2] Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease [J].

Gladwin, MT ;

Shelhamer, JH ;

Ognibene, FP ;

Pease-Fye, ME ;

Nichols, JS ;

Link, B ;

Patel, DB ;

Jankowski, MA ;

Pannell, LK ;

Schechter, AN ;

Rodgers, GP .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 116 (02) :436-444

[3] Chronic transfusion therapy for children with sickle cell disease and recurrent acute chest syndrome [J].

Hankins, J ;

Jeng, M ;

Harris, S ;

Li, CS ;

Liu, TB ;

Wang, W .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2005, 27 (03) :158-161

[4] Nitric oxide production from hydroxyurea [J].

King, SB .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (06) :737-744

[5] Asthma in children with sickle cell disease and its association with acute chest syndrome [J].

Knight-Madden, JM ;

Forrester, TS ;

Lewis, NA ;

Greenough, A .

THORAX, 2005, 60 (03) :206-210

[6] Prevalence and reversibility of lower airway obstruction in children with sickle cell disease [J].

Koumbourlis, AC ;

Zar, HJ ;

Hurlet-Jensen, A ;

Goldberg, MR .

JOURNAL OF PEDIATRICS, 2001, 138 (02) :188-192

[7] Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension [J].

Machado, RF ;

Gladwin, MT .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 129 (04) :449-464

[8] Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia [J].

Miller, ST ;

Wright, E ;

Abboud, M ;

Berman, B ;

Files, B ;

Seber, CD ;

Styles, L ;

Adams, RJ .

JOURNAL OF PEDIATRICS, 2001, 139 (06) :785-789

[9] Hydroxyurea and arginine therapy: Impact on nitric oxide production in sickle cell disease [J].

Morris, CR ;

Vichinsky, EP ;

van Warmerdam, J ;

Machado, L ;

Kepka-Lenhart, D ;

Morris, SM ;

Kuypers, FA .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2003, 25 (08) :629-634

[10] Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease [J].

Quinn, CT ;

Ahmad, N .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 131 (01) :129-134

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