Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group

被引：25

作者：

Key, Nigel S. ^{[1
]}

Khorana, Alok A. ^{[2
]}

Mackman, Nigel ^{[1
]}

McCarty, Owen J. T. ^{[3
]}

White, Gilbert C. ^{[4
]}

Francis, Charles W. ^{[5
,6
]}

McCrae, Keith R. ^{[2
,7
]}

Palumbo, Joseph S. ^{[8
]}

Raskob, Gary E. ^{[9
]}

Chan, Andrew T. ^{[10
,11
]}

Sood, Anil K. ^{[12
,13
]}

机构：

[1] Univ North Carolina Chapel Hill, Div Hematol Oncol, Chapel Hill, NC 27599 USA

[2] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Oncol, Cleveland, OH USA

[3] Oregon Hlth & Sci Univ, Dept Biomed Engn & Cell & Dev Biol, Portland, OR USA

[4] Med Coll Wisconsin, Blood Res Inst, Blood Ctr Wisconsin, Dept Med Biochem & Pharmacol, Milwaukee, WI 53226 USA

[5] Univ Rochester, James P Wilmot Canc Ctr, Rochester, NY USA

[6] Univ Rochester, Dept Med, Rochester, NY USA

[7] Cleveland Clin, Dept Cellular & Mol Med, Cleveland, OH 44106 USA

[8] Cincinnati Childrens Hosp Med Ctr, Div Hematol, Cincinnati, OH 45229 USA

[9] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK USA

[10] Massachusetts Gen Hosp, Dept Med, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA

[11] Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Boston, MA 02114 USA

[12] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA

[13] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CANCER RESEARCH | 2016年 / 76卷 / 13期

关键词：

VENOUS THROMBOEMBOLISM; TISSUE FACTOR; ORAL RIVAROXABAN; TUMOR-CELLS; MICROPARTICLES; THROMBOPROPHYLAXIS; PROPHYLAXIS; WARFARIN; SURGERY; DNA;

D O I：

10.1158/0008-5472.CAN-15-3100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The risk for venous thromboembolism (VTE) is increased in cancer and particularly with chemotherapy, and it portends poorer survival among patients with cancer. However, many fundamental questions about cancer-associated VTE, or Trousseau syndrome, remain unanswered. This report summarizes the proceedings of a working group assembled by the NCI and NHLBI in August 2014 to explore the state of the science in cancer-associated VTE, identify clinically important research gaps, and develop consensus on priorities for future research. Representing a convergence of research priorities between the two NIH Institutes, the workshop addressed epidemiologic, basic science, clinical, and translational issues in cancer-associated VTE. (C) 2016 AACR.

引用

页码：3671 / 3675

页数：5

共 36 条

[1] A clinical outcome-based prospective study on venous thromboembolism after cancer surgery -: The @RISTOS project [J].

Agnelli, G ;

Bolis, G ;

Capussotti, L ;

Scarpa, RM ;

Tonelli, F ;

Bonizzoni, E ;

Moia, M ;

Parazzini, F ;

Rossi, R ;

Sonaglia, F ;

Valarani, B ;

Bianchini, C ;

Gussoni, G ;

Andreoni, B ;

Biffi, R ;

Cenciarelli, S ;

Capussotti, L ;

Calgaro, M ;

Polastri, R ;

Zorzi, D ;

Mazzini, G ;

Tubaro, A ;

Perna, R ;

Vicentini, C ;

Montemurro, S ;

Caliandro, C ;

Ruggeri, E ;

Gennari, L ;

Brocchi, A ;

Quagliuolo, V ;

Scarpa, RM ;

Ragni, F ;

Conti, G ;

Cretarola, E ;

Pagliarulo, A ;

D'Achille, G ;

Bartoli, A ;

Bussotti, C ;

Ricci, E ;

Servoli, A ;

Carrieri, G ;

Corvasce, T ;

Disabato, G ;

Moretti, R ;

Bencini, L ;

Cantafio, S ;

Scatizzi, M ;

Scambia, G ;

Foti, E ;

Frigerio, L .

ANNALS OF SURGERY, 2006, 243 (01) :89-95

[2] High D-dimer levels are associated with poor prognosis in cancer patients [J].

Ay, Cihan ;

Dunkler, Daniela ;

Pirker, Robert ;

Thaler, Johannes ;

Quehenberger, Peter ;

Wagner, Oswald ;

Zielinski, Christoph ;

Pabinger, Ingrid .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (08) :1158-1164

[3] Prediction of venous thromboembolism in cancer patients [J].

Ay, Cihan ;

Dunkler, Daniela ;

Marosi, Christine ;

Chiriac, Alexandru-Laurentiu ;

Vormittag, Rainer ;

Simanek, Ralph ;

Quehenberger, Peter ;

Zielinski, Christoph ;

Pabinger, Ingrid .

BLOOD, 2010, 116 (24) :5377-5382

[4] Oral Rivaroxaban for Symptomatic Venous Thromboembolism. [J].

Bauersachs, Rupert ;

Berkowitz, Scott D. ;

Brenner, Benjamin ;

Buller, Harry R. ;

Decousus, Herve ;

Gallus, Alex S. ;

Lensing, Anthonie W. ;

Misselwitz, Frank ;

Prins, Martin H. ;

Raskob, Gary E. ;

Segers, Annelise ;

Verhamme, Peter ;

Wells, Phil ;

Agnelli, Giancarlo ;

Bounameaux, Henri ;

Cohen, Alexander ;

Davidson, Bruce L. ;

Piovella, Franco ;

Schellong, Sebastian .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (26) :2499-2510

[5]

Bergqvist D, 1997, BRIT J SURG, V84, P1099

[6] Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. [J].

Bergqvist, D ;

Agnelli, G ;

Cohen, AT ;

Eldor, A ;

Nilsson, PE ;

Le Moigne-Amrani, A ;

Dietrich-Neto, F .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (13) :975-980

[7] The role of platelet activation in tumor metastasis [J].

Borsig, Lubor .

EXPERT REVIEW OF ANTICANCER THERAPY, 2008, 8 (08) :1247-1255

[8] Neutrophil extracellular traps kill bacteria [J].

Brinkmann, V ;

Reichard, U ;

Goosmann, C ;

Fauler, B ;

Uhlemann, Y ;

Weiss, DS ;

Weinrauch, Y ;

Zychlinsky, A .

SCIENCE, 2004, 303 (5663) :1532-1535

[9] Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism [J].

Buller, Harry R. ;

Prins, Martin H. ;

Lensing, Anthonie W. A. ;

Decousus, Herve ;

Jacobson, Barry F. ;

Minar, Erich ;

Chlumsky, Jaromir ;

Verhamme, Peter ;

Wells, Phil ;

Agnelli, Giancarlo ;

Cohen, Alexander ;

Berkowitz, Scott D. ;

Bounameaux, Henri ;

Davidson, Bruce L. ;

Misselwitz, Frank ;

Gallus, Alex S. ;

Raskob, Gary E. ;

Schellong, Sebastian ;

Segers, Annelise .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (14) :1287-1297

[10] Rates of venous thromboembolism in multiple myeloma patients undergoing immunomodulatory therapy with thalidomide or lenalidomide: a systematic review and meta-analysis [J].

Carrier, M. ;

Le Gal, G. ;

Tay, J. ;

Wu, C. ;

Lee, A. Y. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (04) :653-663

← 1 2 3 4 →