Molecular review of odontogenic myxoma

被引：26
作者：
Gomes, Carolina Cavalieri [2 ]
Diniz, Marina Goncalves [1 ]
Duarte, Alessandra Pires [1 ]
Bernardes, Vanessa Fatima [1 ]
Gomez, Ricardo Santiago [1 ]
机构：
[1] Univ Fed Minas Gerais, Dept Oral Surg & Pathol, Sch Dent, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Pathol, BR-31270901 Belo Horizonte, MG, Brazil
来源：
ORAL ONCOLOGY | 2011年 / 47卷 / 05期
关键词：
Odontogenic myxoma; Odontogenic tumors; Clonal nature; Matrix metalloproteinases; Apoptosis; Cell proliferation; Pathogenesis; MATRIX METALLOPROTEINASES; REGULATORY SUBUNIT; NESTIN EXPRESSION; CARNEY COMPLEX; MUTATIONS; GENE; JAWS; TUMORS; MYXOFIBROMA; PROTEINS;
D O I：
10.1016/j.oraloncology.2011.03.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Odontogenic myxoma (OM) is a benign odontogenic neoplasm that tends to recur due to bone infiltration. This review focuses on the molecular aspects of the OM. The following topics are discussed: clonal nature, matrix metalloproteinases, apoptosis and cell proliferation, genetic alterations, and other markers. Translational studies are necessary to identify the prognostic markers of this lesion, and also, molecular biology studies may help to identify the etiologic factors and to develop more effective and less aggressive approaches, other than surgery, to the treatment of this infiltrating odontogenic tumor. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：325 / 328
页数：4
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