You've got to be kindlin!

被引：2

作者：

Simon, Scott I. ^{[1
]}

机构：

[1] Univ Calif Davis, Davis, CA 95616 USA

来源：

BLOOD | 2015年 / 125卷 / 12期

关键词：

INTEGRIN ACTIVATION;

D O I：

10.1182/blood-2015-02-623843

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Liao et al report that kindlin-2 is necessary for angiogenic sprouting in vitro and for developmental and tumor angiogenesis in vivo.(1) The process of blood vessel sprouting is known to involve the alpha V beta 3 vitronectin integrin on endothelium. Kindlin-2 linkage to the C-terminal tail of beta 3 completed the outside-in circuit necessary for integrin signaling that is critical for navigation of new vessel sprouts.

引用

收藏

页码：1855 / 1856

页数：4

相关论文

共 50 条

[31] Kindlin-1 is a key protein in hyperbaric oxygen therapy for the treatment of neuropathic pain [J].

Zhao, Baisong ;

He, Erning ;

Pan, Yongying ;

Xu, Haiping ;

Song, Xingrong .

MOLECULAR PAIN, 2017, 13

[32] miR-138-Mediated Regulation of KINDLIN-2 Expression Modulates Sensitivity to Chemotherapeutics [J].

Sossey-Alaoui, Khalid ;

Plow, Edward F. .

MOLECULAR CANCER RESEARCH, 2016, 14 (02) :228-238

[33] Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice [J].

Zhu, Ke ;

Lai, Yumei ;

Cao, Huiling ;

Bai, Xiaochun ;

Liu, Chuanju ;

Yan, Qinnan ;

Ma, Liting ;

Chen, Di ;

Kanaporis, Giedrius ;

Wang, Junqi ;

Li, Luyuan ;

Cheng, Tao ;

Wang, Yong ;

Wu, Chuanyue ;

Xiao, Guozhi .

NATURE COMMUNICATIONS, 2020, 11 (01)

[34] Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages [J].

Meller, Julia ;

Chen, Zhihong ;

Dudiki, Tejasvi ;

Cull, Rebecca M. ;

Murtazina, Rakhilya ;

Bal, Saswat K. ;

Pluskota, Elzbieta ;

Stefl, Samantha ;

Plow, Edward F. ;

Trapp, Bruce D. ;

Byzova, Tatiana V. .

JCI INSIGHT, 2017, 2 (11)

[35] Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1 [J].

Gao, Juan ;

Bao, Yun ;

Ge, Shushu ;

Sun, Peisen ;

Sun, Jiaojiao ;

Liu, Jianmin ;

Chen, Feng ;

Han, Li ;

Cao, Zhongyuan ;

Qin, Jun ;

White, Gilbert C. ;

Xu, Zhen ;

Ma, Yan-Qing .

CELL COMMUNICATION AND SIGNALING, 2019, 17 (01)

[36] A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections [J].

Boudreaux, Mary K. ;

Wardrop, K. Jane ;

Kiklevich, Veronika ;

Felsburg, Peter ;

Snekvik, Kevin .

THROMBOSIS AND HAEMOSTASIS, 2010, 103 (02) :475-477

[37] Paxillin: A Hub for Mechano-Transduction from the β3 Integrin-Talin-Kindlin Axis [J].

Ripamonti, Marta ;

Wehrle-Haller, Bernhard ;

de Curtis, Ivan .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10

[38] Kindlin-3 in Immune Cells Is Required to Suppress Prostate Cancer Tumor Growth in Mice [J].

Liu, Cheng ;

Zhou, Ying ;

Zhou, Yu ;

Xu, Zhen ;

Ma, Yan-Qing .

ANTICANCER RESEARCH, 2022, 42 (03) :1217-1220

[39] Crystallization and preliminary X-ray crystallographic analysis of the human kindlin-2 PH domain [J].

Lee, Jun Hyuck ;

An, Jun Yop ;

Park, HaJeung ;

Kim, Hak Jun ;

Eom, Soo Hyun .

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 67 :696-699

[40] Kindlin-3 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial Infarction [J].

Sun, Yan ;

Zheng, Wei ;

Liu, Xianling ;

Wang, Kai ;

Xu, Di .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2025, 29 (06)

← 1 2 3 4 5 →