You've got to be kindlin!

被引：2

作者：

Simon, Scott I. ^{[1
]}

机构：

[1] Univ Calif Davis, Davis, CA 95616 USA

来源：

BLOOD | 2015年 / 125卷 / 12期

关键词：

INTEGRIN ACTIVATION;

D O I：

10.1182/blood-2015-02-623843

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Liao et al report that kindlin-2 is necessary for angiogenic sprouting in vitro and for developmental and tumor angiogenesis in vivo.(1) The process of blood vessel sprouting is known to involve the alpha V beta 3 vitronectin integrin on endothelium. Kindlin-2 linkage to the C-terminal tail of beta 3 completed the outside-in circuit necessary for integrin signaling that is critical for navigation of new vessel sprouts.

引用

收藏

页码：1855 / 1856

页数：4

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