You've got to be kindlin!

被引：2
作者：
Simon, Scott I. [1 ]
机构：
[1] Univ Calif Davis, Davis, CA 95616 USA
来源：
BLOOD | 2015年 / 125卷 / 12期
关键词：
INTEGRIN ACTIVATION;
D O I：
10.1182/blood-2015-02-623843
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Liao et al report that kindlin-2 is necessary for angiogenic sprouting in vitro and for developmental and tumor angiogenesis in vivo.(1) The process of blood vessel sprouting is known to involve the alpha V beta 3 vitronectin integrin on endothelium. Kindlin-2 linkage to the C-terminal tail of beta 3 completed the outside-in circuit necessary for integrin signaling that is critical for navigation of new vessel sprouts.
引用
收藏
页码：1855 / 1856
页数：4
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