Antiplasmodial and Cytotoxic Triterpenoids from the Bark of the Cameroonian Medicinal Plant Entandrophragma congoense

被引：32
|
作者：
Happi, Gervais Mouthe [1 ,2 ]
Kouam, Simeon Fogue [1 ]
Talontsi, Ferdinand Mouafo [2 ]
Lamshoeft, Marc [2 ]
Zuehlke, Sebastian [2 ]
Bauer, Jonathan O. [3 ]
Strohmann, Carsten [3 ]
Spiteller, Michael [2 ]
机构：
[1] Univ Yaounde I, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon
[2] Inst Environm Res INFU, Fac Chem & Chem Biol, Chair Environm Chem & Analyt Chem, D-44221 Dortmund, Germany
[3] TU Dortmund, Dept Chem & Chem Biol, Inorgan Chem, D-44221 Dortmund, Germany
来源：
JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 04期
关键词：
ACYCLIC TRITERPENOIDS; STEM BARK; ABSOLUTE-CONFIGURATION; PLASMODIUM-FALCIPARUM; LIMONOIDS; TETRANORTRITERPENOIDS; PROTOLIMONOIDS; RESISTANCE; ASSAY;
D O I：
10.1021/np5004164
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eight new triterpenoids, prototiamins A-G (1-6, 9) and seco-tiaminic acid A (10), were isolated along with four known compounds from the bark of Entandrophragma congoense. Their structures were elucidated by means of HRMS and different NMR techniques and chemical transformations. Assignments of relative and absolute configurations for the new compounds were achieved using NOESY experiments and by chemical modification including the advanced Mosher's method Additionally, the structure and relative configuration of compound 3 were confirmed by single-crystal X-ray diffraction analysis. Compounds 1, 3, and 5 displayed significant hi vitro antiplasmodial activity against the erythrocytic stages of chloroquine-sensitive Plasmodium falciparum strain NF54. Prototiamin C (3) was the most potent of the compounds isolated, with an IC50 value of 0.44 mu M. All compounds tested showed low C toxicity for the L6 rat skeletal myoblast cell line:
引用
收藏
页码：604 / 614
页数：11
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