Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus

被引：39
作者：
Mase, M [1 ]
Yamada, K
Shimazu, N
Seiki, K
Oda, H
Nakau, H
Inui, T
Li, WD
Eguchi, N
Urade, Y
机构：
[1] Nagoya City Univ, Grad Sch Med Sci, Dept Neurosurg & Restorat Neurosci, Nagoya, Aichi 4678602, Japan
[2] Okuma Hosp, Dept Neurosurg, Nagoya, Aichi 4620822, Japan
[3] Maruha Corp, Cent Res Inst, Dept Biol Chem, Tsukuba, Ibaraki 3004295, Japan
[4] Osaka Biosci Inst, Dept Mol Behav Biol, Osaka 5650874, Japan
[5] Osaka Biosci Inst, Japan Sci & Technol Corp, CREST, Osaka 5650874, Japan
[6] Tsu City Coll, Dept Food & Nutr, Tsu, Mie, Japan
来源：
NEUROSCIENCE RESEARCH | 2003年 / 47卷 / 04期
关键词：
lipocalin-type prostaglandin D synthase; beta-trace protein; normal pressure hydrocephalus; cerebrospinal fluid; dementia;
D O I：
10.1016/j.neures.2003.08.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Lipocalin-type prostaglandin D synthase (PGDS) is considered to be mainly produced in the leptomeninges and secreted into cerebrospinal fluid (CSF). We found PGDS levels in CSF of patients with normal pressure hydrocephalus (NPH) (8.99 +/- 2.59 mug/ml, mean +/- S.D., n = 14) to be significantly lower than levels in a control (15.29 +/- 5.17, n = 14, P < 0.0001) and other dementia group (19.14 +/- 4.34, n = 7, P = 0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia. (C) 2003 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：455 / 459
页数：5
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