Synthesis of Isotope-Labeled Deoxynivalenol-15-O-Glycosides

被引：2

作者：

Weber, Julia ^{[1
]}

Fruhmann, Philipp ^{[1
,2
]}

Hametner, Christian ^{[1
]}

Schiessl, Alois ^{[3
]}

Haeubl, Georg ^{[3
]}

Froehlich, Johannes ^{[1
]}

Mikula, Hannes ^{[1
]}

机构：

[1] Vienna Univ Technol TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9, A-1060 Vienna, Austria

[2] CEST, Viktor Kaplan Str 2, A-2700 Wiener Neustadt, Austria

[3] Romer Labs, Technopk 1, A-3430 Tulln Donau, Austria

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 47期

关键词：

Glycosylation; Glycosides; Orthoesters; Natural products; Isotopic labeling; ACETYLATED DERIVATIVES; CHEMICAL-SYNTHESIS; MASKED MYCOTOXINS; O-GLYCOSYLATION; DEOXYNIVALENOL; ACID; GLUCOSIDE; ANALOGS; WHEAT;

D O I：

10.1002/ejoc.201700934

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile and efficient protocol for the Schmidt glycosylation of 3-acetyldeoxynivalenol (3-ADON) and subsequent deprotection has been developed to gain access to deoxynivalenol-15-O-glycosides in reasonable amounts for biological analysis and further investigations. By using this protocol with [C-13(6)]glycosyl donors, we were able to prepare isotope-labeled deoxynivalenol-15-O-glycosides, which are pivotal to enabling accurate quantification of masked mycotoxins by LC-MS.

引用

页码：7012 / 7018

页数：7

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