NF-κB signaling and human disease

被引：85
作者：
Aradhya, S [1 ]
Nelson, DL [1 ]
机构：
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 03期
关键词：
D O I：
10.1016/S0959-437X(00)00194-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Despite substantial progress in understanding the NF-kappaB signaling pathway, the connections between this pathway and human disease are only now being elucidated. Genes that function within or upstream of the NF-kappaB pathway have been found to cause four distinct disorders and two allelic conditions. Investigation of these genes and disorders has brought significant insight into the role of NF-kappaB in various aspects of physiological development.
引用
收藏
页码：300 / 306
页数：7
相关论文
共 63 条
  • [1] SUPPRESSION OF RETINAL NEOVASCULARIZATION IN-VIVO BY INHIBITION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) USING SOLUBLE VEGF-RECEPTOR CHIMERIC PROTEINS
    AIELLO, LP
    PIERCE, EA
    FOLEY, ED
    TAKAGI, H
    CHEN, H
    RIDDLE, L
    FERRARA, N
    KING, GL
    SMITH, LEH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) : 10457 - 10461
  • [2] Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-γ)
    Aradhya, S
    Courtois, G
    Rajkovic, A
    Lewis, RA
    Levy, M
    Israël, A
    Nelson, DL
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (03) : 765 - 771
  • [3] NF-kappa B: Ten years after
    Baeuerle, PA
    Baltimore, D
    [J]. CELL, 1996, 87 (01) : 13 - 20
  • [4] BAEUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141, DOI 10.1146/annurev.immunol.12.1.141
  • [5] Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases
    Barnes, PJ
    Larin, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) : 1066 - 1071
  • [6] EMBRYONIC LETHALITY AND LIVER DEGENERATION IN MICE LACKING THE RELA COMPONENT OF NF-KAPPA-B
    BEG, AA
    SHA, WC
    BRONSON, RT
    GHOSH, S
    BALTIMORE, D
    [J]. NATURE, 1995, 376 (6536) : 167 - 170
  • [7] An essential role for NF-kappa B in preventing TNF-alpha-induced cell death
    Beg, AA
    Baltimore, D
    [J]. SCIENCE, 1996, 274 (5288) : 782 - 784
  • [8] Required and nonessential functions of nuclear factor-kappa B in bone cells
    Boyce, BF
    Xing, L
    Franzoso, G
    Siebenlist, U
    [J]. BONE, 1999, 25 (01) : 137 - 139
  • [9] Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis
    Bushdid, PB
    Brantley, DM
    Yull, FE
    Blaeuer, GL
    Hoffman, LH
    Niswander, L
    Kerr, LD
    [J]. NATURE, 1998, 392 (6676) : 615 - 618
  • [10] X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling
    Döffinger, R
    Smahi, A
    Bessia, C
    Geissmann, F
    Feinberg, J
    Durandy, A
    Bodemer, C
    Kenwrick, S
    Dupuis-Girod, S
    Blanche, S
    Wood, P
    Rabia, SH
    Headon, DJ
    Overbeek, PA
    Le Deist, F
    Holland, SM
    Belani, K
    Kumararatne, DS
    Fischer, A
    Shapiro, R
    Conley, ME
    Reimund, E
    Kalhoff, H
    Abinun, M
    Munnich, A
    Israël, A
    Courtois, G
    Casanova, JL
    [J]. NATURE GENETICS, 2001, 27 (03) : 277 - 285
1234567