BRCA1/2 associated hereditary breast cancer

被引：15

作者：

Teng, Li-Song ^{[1
]}

Zheng, Yi ^{[1
]}

Wang, Hao-Hao ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Ctr Canc, Hangzhou 310003, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2008年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

BRCA1; BRCA2; hereditary breast cancer;

D O I：

10.1631/jzus.B0710617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

引用

页码：85 / 89

页数：5

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