Molecular definition of group 1 innate lymphoid cells in the mouse uterus

被引：72

作者：

Filipovic, Iva ^{[1
,2
,3
]}

Chiossone, Laura ^{[4
,10
]}

Vacca, Paola ^{[5
,6
,7
]}

Hamilton, Russell S. ^{[3
]}

Ingegnere, Tiziano ^{[7
]}

Doisne, Jean-Marc ^{[1
,11
]}

Hawkes, Delia A. ^{[1
]}

Mingari, Maria Cristina ^{[5
,6
,8
]}

Sharkey, Andrew M. ^{[3
,9
]}

Moretta, Lorenzo ^{[7
]}

Colucci, Francesco ^{[1
,3
]}

机构：

[1] Univ Cambridge, Dept Obstet & Gynaecol, NIHR Cambridge Biomed Res Ctr, Sch Clin Med, Cambridge CB2 0SW, England

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

[3] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England

[4] G Gaslini Inst Children, Genoa, Italy

[5] Policlin San Martino IRCCS Oncol, I-16132 Genoa, Italy

[6] Univ Genoa, Dept Expt Med DIMES, I-16132 Genoa, Italy

[7] IRCCS Bambino Gesu Childrens Hosp, Dept Immunol, I-00165 Rome, Italy

[8] Univ Genoa, CEBR, I-16132 Genoa, Italy

[9] Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England

[10] Innate Pharma, Innate Pharma Res Labs, F-13009 Marseille, France

[11] Pasteur Inst, Dept Immunol, F-75015 Paris, France

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

英国惠康基金;

关键词：

UTERINE NK CELLS; CHEMOKINE RECEPTOR CXCR6; FATTY-ACID SYNTHESIS; DECIDUAL NK; MATERNAL KIR; B-CELLS; EXPRESSION; MEMORY; LIVER; INFLAMMATION;

D O I：

10.1038/s41467-018-06918-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes(+)CD49a(+) NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-beta responses and interactions with trophoblast, epithelial, endothelial, smooth muscle cells, leucocytes and extracellular matrix. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-gamma. Eomes(-)CD49a(+) ILC1s dominate before puberty, and specifically expand in second pregnancies when the expression of the memory cell marker CXCR6 is upregulated. These results identify trNK cells as the cellular hub of uterine group 1 ILCs, and mark CXCR6(+) ILC1s as potential memory cells of pregnancy.

引用

页数：13

共 72 条

[1]

Allen MP, 1998, J IMMUNOL, V161, P2772

[2] Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface [J].

Arenas-Hernandez, Marcia ;

Sanchez-Rodriguez, Elly N. ;

Mial, Tara N. ;

Robertson, Sarah A. ;

Gomez-Lopez, Nardhy .

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2015, (99)

[3] Interferon γ contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [J].

Ashkar, AA ;

Di Santo, JP ;

Croy, BA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :259-269

[4] Srebp-controlled glucose metabolism is essential for NK cell functional responses [J].

Assmann, Nadine ;

O'Brien, Katie L. ;

Donnelly, Raymond P. ;

Dyck, Lydia ;

Zaiatz-Bittencourt, Vanessa ;

Loftus, Roisin M. ;

Heinrich, Paul ;

Oefner, Peter J. ;

Lynch, Lydia ;

Gardiner, Clair M. ;

Dettmer, Katja ;

Finlay, David K. .

NATURE IMMUNOLOGY, 2017, 18 (11) :1197-+

[5] IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs [J].

Bal, Suzanne M. ;

Bernink, Jochem H. ;

Nagasawa, Maho ;

Groot, Jelle ;

Shikhagaie, Medya M. ;

Golebski, Kornel ;

van Drunen, Cornelis M. ;

Lutter, Rene ;

Jonkers, Rene E. ;

Hombrink, Pleun ;

Bruchard, Melanie ;

Villaudy, Julien ;

Munneke, J. Marius ;

Fokkens, Wytske ;

Erjefalt, Jonas S. ;

Spits, Hergen ;

Ros, Xavier Romero .

NATURE IMMUNOLOGY, 2016, 17 (06) :636-+

[6] IL-33-Responsive Group 2 Innate Lymphoid Cells Are Regulated by Female Sex Hormones in the Uterus [J].

Bartemes, Kathleen ;

Chen, Chien-Chang ;

Iijima, Koji ;

Drake, Li ;

Kita, Hirohito .

JOURNAL OF IMMUNOLOGY, 2018, 200 (01) :229-236

[7] Human type 1 innate lymphoid cells accumulate in inflamed mucosa! tissues [J].

Bernink, Jochem H. ;

Peters, Charlotte P. ;

Munneke, Marius ;

te Velde, Anje A. ;

Meijer, Sybren L. ;

Weijer, Kees ;

Hreggvidsdottir, Hulda S. ;

Heinsbroek, Sigrid E. ;

Legrand, Nicolas ;

Buskens, Christianne J. ;

Bemelman, Willem A. ;

Mjosberg, Jenny M. ;

Spits, Hergen .

NATURE IMMUNOLOGY, 2013, 14 (03) :221-229

[8] De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells [J].

Berod, Luciana ;

Friedrich, Christin ;

Nandan, Amrita ;

Freitag, Jenny ;

Hagemann, Stefanie ;

Harmrolfs, Kirsten ;

Sandouk, Aline ;

Hesse, Christina ;

Castro, Carla N. ;

Baehres, Heike ;

Tschirner, Sarah K. ;

Gorinski, Nataliya ;

Gohmert, Melanie ;

Mayer, Christian T. ;

Huehn, Jochen ;

Ponimaskin, Evgeni ;

Abraham, Wolf-Rainer ;

Mueller, Rolf ;

Lochner, Matthias ;

Sparwasser, Tim .

NATURE MEDICINE, 2014, 20 (11) :1327-1333

[9] The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy [J].

Boulenouar, Selma ;

Doisne, Jean-Marc ;

Sferruzzi-Perri, Amanda ;

Gaynor, Louise M. ;

Kieckbusch, Jens ;

Balmas, Elisa ;

Yung, Hong Wa ;

Javadzadeh, Shagayegh ;

Volmer, Lea ;

Hawkes, Delia A. ;

Phillips, Keli ;

Brady, Hugh J. M. ;

Fowden, Abigail L. ;

Burton, Graham J. ;

Moffett, Ashley ;

Colucci, Francesco .

FRONTIERS IN IMMUNOLOGY, 2016, 7

[10]

CHEN Z, 2012, BIOL REPROD, V87, P1

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