Intravenous arketamine for treatment-resistant depression: open-label pilot study

被引：177

作者：

Leal, Gustavo C. ^{[1
,2
,3
]}

Bandeira, Igor D. ^{[2
,3
]}

Correia-Melo, Fernanda S. ^{[2
,3
]}

Telles, Manuela ^{[2
,3
]}

Mello, Rodrigo P. ^{[2
,3
]}

Vieira, Flavia ^{[2
,3
]}

Lima, Cassio S. ^{[2
,3
,4
]}

Jesus-Nunes, Ana Paula ^{[2
,3
]}

Guerreiro-Costa, Livia N. F. ^{[2
,3
]}

Marback, Roberta F. ^{[2
]}

Caliman-Fontes, Ana Teresa ^{[2
]}

Marques, Breno L. S. ^{[2
,4
]}

Bezerra, Marilia L. O. ^{[2
,4
]}

Dias-Neto, Alberto L. ^{[2
]}

Silva, Samantha S. ^{[2
]}

Sampaio, Aline S. ^{[2
,3
,5
]}

Sanacora, Gerard ^{[6
]}

Turecki, Gustavo ^{[7
,8
]}

Loo, Colleen ^{[9
,10
]}

Lacerda, Acioly L. T. ^{[11
,12
]}

Quarantini, Lucas C. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Serv Psiquiatria, 3 Andar,Rua Dr Augusto Viana S-N, BR-40110060 Salvador, BA, Brazil

[2] Univ Fed Bahia, Lab Neuropsicofarmacol, Salvador, BA, Brazil

[3] Univ Fed Bahia, Fac Med Bahia, Programa Posgrad Med & Saude, Salvador, BA, Brazil

[4] Univ Fed Bahia, Lab Pesquisa Neuropsicol Clin & Cognit, Salvador, BA, Brazil

[5] Univ Fed Bahia, Fac Med Bahia, Dept Neurociencias & Saude Mental, Salvador, BA, Brazil

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[7] Douglas Mental Hlth Univ Inst, Dept Psychiat, McGill Grp Suicide Studies, Montreal, PQ, Canada

[8] McGill Univ, Montreal, PQ, Canada

[9] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[10] Black Dog Inst, Sydney, NSW, Australia

[11] Univ Fed Sao Paulo, Lab Interdisciplinar Neurociencias Clin, Sao Paulo, SP, Brazil

[12] Inst Sinapse Neurociencias Clin, Campinas, SP, Brazil

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2021年 / 271卷 / 03期

关键词：

Arketamine; (R)-Ketamine; Ketamine; Major depressive disorder; Treatment-resistant depression; Rapid-acting antidepressant; DOUBLE-BLIND; ORAL ANTIDEPRESSANT; BIPOLAR DEPRESSION; KETAMINE ISOMERS; RAPID TREATMENT; ESKETAMINE; EFFICACY; PHARMACOLOGY; (R)-KETAMINE; METAANALYSIS;

D O I：

10.1007/s00406-020-01110-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery-angstrom sberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6-27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed.

引用

页码：577 / 582

页数：6

共 31 条

[1] Antidepressant effects of ketamine in depressed patients
Berman, RM
Cappiello, A
Anand, A
Oren, DA
Heninger, GR
Charney, DS
Krystal, JH
[J]. BIOLOGICAL PSYCHIATRY, 2000, 47 (04) : 351 - 354
[2] Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS)
Bremner, JD
Krystal, JH
Putnam, FW
Southwick, SM
Marmar, C
Charney, DS
Mazure, CM
[J]. JOURNAL OF TRAUMATIC STRESS, 1998, 11 (01) : 125 - 136
[3] Ketamine and other glutamate receptor modulators for depression in adults
Caddy, Caroline
Amit, Ben H.
McCloud, Tayla L.
Rendell, Jennifer M.
Furukawa, Toshi A.
McShane, Rupert
Hawton, Keith
Cipriani, Andrea
[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (09):
[4] Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study
Canuso, Carla M.
Singh, Jaskaran B.
Fedgchin, Maggie
Alphs, Larry
Lane, Rosanne
Lim, Pilar
Pinter, Christine
Hough, David
Sanacora, Gerard
Manji, Husseini
Drevets, Wayne C.
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2018, 175 (07) : 620 - 630
[5] Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study
Correia-Melo, Fernanda S.
Leal, Gustavo C.
Vieira, Flavia
Jesus-Nunes, Ana Paula
Mello, Rodrigo P.
Magnavita, Guilherme
Caliman-Fontes, Ana Teresa
Echegaray, Mariana V. F.
Bandeira, Igor D.
Silva, Samantha S.
Cavalcanti, Diogo E.
Araujo-de-Freitas, Lucas
Sarin, Luciana M.
Tuena, Marco A.
Nakahira, Carolina
Sampaio, Aline S.
Del-Porto, Jose A.
Turecki, Gustavo
Loo, Colleen
Lacerda, Acioly L. T.
Quarantini, Lucas C.
[J]. JOURNAL OF AFFECTIVE DISORDERS, 2020, 264 : 527 - 534
[6] Rapid infusion of esketamine for unipolar and bipolar depression: a retrospective chart review
Correia-Melo, Fernanda S.
Argolo, Felipe C.
Araujo-de-Freitas, Lucas
Leal, Gustavo Carneiro
Kapczinski, Flavio
Lacerda, Acioly Luiz
Quarantini, Lucas C.
[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2017, 13 : 1627 - 1632
[7] Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression A Randomized Clinical Trial
Daly, Ella J.
Singh, Jaskaran B.
Fedgchin, Maggie
Cooper, Kimberly
Lim, Pilar
Shelton, Richard C.
Thase, Michael E.
Winokur, Andrew
Van Nueten, Luc
Manji, Husseini
Drevets, Wayne C.
[J]. JAMA PSYCHIATRY, 2018, 75 (02) : 139 - 148
[8] Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)
Fedgchin, Maggie
Trivedi, Madhukar
Daly, Ella J.
Melkote, Rama
Lane, Rosanne
Lim, Pilar
Vitagliano, Dawn
Blier, Pierre
Fava, Maurizio
Liebowitz, Michael
Ravindran, Arun
Gaillard, Raphael
van den Ameele, Hans
Preskorn, Sheldon
Manji, Husseini
Hough, David
Drevets, Wayne C.
Singh, Jaskaran B.
[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2019, 22 (10) : 616 - 630
[9] Ketamine administration in depressive disorders: a systematic review and meta-analysis
Fond, Guillaume
Loundou, Anderson
Rabu, Corentin
Macgregor, Alexandra
Lancon, Christophe
Brittner, Marie
Micoulaud-Franchi, Jean-Arthur
Richieri, Raphaelle
Courtet, Philippe
Abbar, Mocrane
Roger, Matthieu
Leboyer, Marion
Boyer, Laurent
[J]. PSYCHOPHARMACOLOGY, 2014, 231 (18) : 3663 - 3676
[10] Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine
Fukumoto, Kenichi
Toki, Hidetoh
Iijima, Michihiko
Hashihayata, Takashi
Yamaguchi, Jun-ichi
Hashimoto, Kenji
Chaki, Shigeyuki
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017, 361 (01) : 9 - 16

← 1 2 3 4 →