Intravenous arketamine for treatment-resistant depression: open-label pilot study

被引：186

作者：

Leal, Gustavo C. ^{[1
,2
,3
]}

Bandeira, Igor D. ^{[2
,3
]}

Correia-Melo, Fernanda S. ^{[2
,3
]}

Telles, Manuela ^{[2
,3
]}

Mello, Rodrigo P. ^{[2
,3
]}

Vieira, Flavia ^{[2
,3
]}

Lima, Cassio S. ^{[2
,3
,4
]}

Jesus-Nunes, Ana Paula ^{[2
,3
]}

Guerreiro-Costa, Livia N. F. ^{[2
,3
]}

Marback, Roberta F. ^{[2
]}

Caliman-Fontes, Ana Teresa ^{[2
]}

Marques, Breno L. S. ^{[2
,4
]}

Bezerra, Marilia L. O. ^{[2
,4
]}

Dias-Neto, Alberto L. ^{[2
]}

Silva, Samantha S. ^{[2
]}

Sampaio, Aline S. ^{[2
,3
,5
]}

Sanacora, Gerard ^{[6
]}

Turecki, Gustavo ^{[7
,8
]}

Loo, Colleen ^{[9
,10
]}

Lacerda, Acioly L. T. ^{[11
,12
]}

Quarantini, Lucas C. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Serv Psiquiatria, 3 Andar,Rua Dr Augusto Viana S-N, BR-40110060 Salvador, BA, Brazil

[2] Univ Fed Bahia, Lab Neuropsicofarmacol, Salvador, BA, Brazil

[3] Univ Fed Bahia, Fac Med Bahia, Programa Posgrad Med & Saude, Salvador, BA, Brazil

[4] Univ Fed Bahia, Lab Pesquisa Neuropsicol Clin & Cognit, Salvador, BA, Brazil

[5] Univ Fed Bahia, Fac Med Bahia, Dept Neurociencias & Saude Mental, Salvador, BA, Brazil

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[7] Douglas Mental Hlth Univ Inst, Dept Psychiat, McGill Grp Suicide Studies, Montreal, PQ, Canada

[8] McGill Univ, Montreal, PQ, Canada

[9] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[10] Black Dog Inst, Sydney, NSW, Australia

[11] Univ Fed Sao Paulo, Lab Interdisciplinar Neurociencias Clin, Sao Paulo, SP, Brazil

[12] Inst Sinapse Neurociencias Clin, Campinas, SP, Brazil

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2021年 / 271卷 / 03期

关键词：

Arketamine; (R)-Ketamine; Ketamine; Major depressive disorder; Treatment-resistant depression; Rapid-acting antidepressant; DOUBLE-BLIND; ORAL ANTIDEPRESSANT; BIPOLAR DEPRESSION; KETAMINE ISOMERS; RAPID TREATMENT; ESKETAMINE; EFFICACY; PHARMACOLOGY; (R)-KETAMINE; METAANALYSIS;

D O I：

10.1007/s00406-020-01110-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery-angstrom sberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6-27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed.

引用

页码：577 / 582

页数：6

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