Successful use of Bruton's kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukaemia

被引：27

作者：

Lee, Andrew ^{[1
,2
]}

Sandhu, Suneet ^{[3
,4
]}

Imlay-Gillespie, Louise ^{[3
]}

Mulligan, Stephen ^{[2
,3
,4
]}

Shumack, Stephen ^{[1
,2
]}

机构：

[1] Royal North Shore Hosp, Dept Dermatol, Reserve Rd, Sydney, NSW, Australia

[2] Univ Sydney, Sydney Med Sch Northern, Sydney, NSW, Australia

[3] Royal North Shore Hosp, Dept Haematol, Sydney, NSW, Australia

[4] Northern Sydney Local Hlth Dist, Kolling Inst, Northern Blood Res Ctr, Sydney, NSW, Australia

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2017年 / 58卷 / 04期

关键词：

chronic lymphocytic leukemia; ibrutinib; PAMS; paraneoplastic pemphigus; B-CELL; DISEASE; MANIFESTATIONS; CYTOPENIAS; MALIGNANCY; BTK;

D O I：

10.1111/ajd.12615

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We present the case of a 51-year-old man who developed paraneoplastic pemphigus (PNP) in the context of chronic lymphocytic leukemia (CLL). His CLL was successfully controlled with ibrutinib. Concurrently, there was significant improvement of his PNP, suggesting that ibrutinib may be a very useful addition to the treatment options in this potentially life-threatening autoimmune disorder.

引用

页码：E240 / E242

页数：3

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