Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

被引：68

作者：

St-Pierre, Julie ^{[1
,2
]}

Tremblay, Michel L. ^{[1
,2
]}

机构：

[1] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[2] McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada

来源：

CELL METABOLISM | 2012年 / 15卷 / 03期

关键词：

MICE LACKING; BODY-WEIGHT; OBESITY; ACTIVATION; INSULIN; PTP1B; SHP2; PHOSPHORYLATION; EPSILON;

D O I：

10.1016/j.cmet.2012.02.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.

引用

页码：292 / 297

页数：6

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