Synthesis and DNA cleavage studies of novel quinoline oxime esters

被引：49

作者：

Bindu, P. J. ^{[1
]}

Mahadevan, K. M. ^{[1
]}

Satyanarayan, N. D. ^{[2
]}

Naik, T. R. Ravikumar ^{[3
]}

机构：

[1] Kuvempu Univ, Dept Studies & Res Chem, Shankaraghatt 577451, India

[2] Kuvempu Univ, PG Ctr, Dept Pharmaceut Chem, Kadur 577548, India

[3] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 02期

关键词：

Quinoline; Oxime ester; DNA; Photo cleavage; PHOTODYNAMIC THERAPY; N-OXIDES; NITROSATION;

D O I：

10.1016/j.bmcl.2011.12.037

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0 degrees C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40 mu M and 80 mu M). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：898 / 900

页数：3

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