QSAR of anticancer compounds.: Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides)

被引：12
作者：
Mekapati, SB
Denny, WA
Kurup, A
Hansch, C
机构：
[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA
[2] Univ Auckland, Fac Med & Hlth Sci, Auckland Canc Soc, Res Ctr, Auckland, New Zealand
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 11期
关键词：
D O I：
10.1016/S0968-0896(01)00109-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
QSAR have been developed for. the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells. This is consistent with other QSAR of anticancer compounds where hydrophobic interactions are found to be unimportant. (C) 2001 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2757 / 2762
页数：6
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